Results 61 to 70 of about 22,391 (242)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Development of Piezoelectric Harvesters with Integrated Trimming Devices
Applied Sciences, 2018 Piezoelectric cantilever harvesters have a large power output at their natural frequency, but in some applications the frequency of ambient vibrations is different from the harvester’s frequency and/or ambient vibrations are periodic with some ...
Alberto Doria +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Parallelising Harvesting [PDF]
, 2006 Metadata harvesting has become a common technique to transfer a stream of data from one metadata repository or digital library system to another. As collections of metadata, and their associated digital objects, grow in size, the ingest of these items at the destination archive can take a significant amount of time, depending on the type of indexing or
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
AgricultureTo address longstanding challenges in sea buckthorn harvesting—such as the absence of effective harvesting principles, inefficient traditional manual and semi-mechanised methods, and rising labour costs—this study developed a self-propelled harvester ...
Jian Song +7 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Autonomous Offroad Vehicle Real-Time Multi-Physics Digital Twin: Modeling and Validation
MachinesThe use of physical vehicles and environments during vehicle research and development is highly resource-intensive, particularly for autonomous vehicles.
Mattias Lehto +3 more
doaj +1 more source
Ciência e Agrotecnologia, 2011 Objetivou-se, no presente trabalho, realizar uma avaliação ergonômica de uma colhedora de cana-de-açúcar, localizada no município de Barra Bonita, estado de São Paulo, em janeiro de 2007.
Carla Bento da Silva +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source