Results 201 to 210 of about 1,168,516 (371)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Balancing Harvesting and Conservation: Demographic Responses of a Threatened Palm to Anthropogenic Disturbance. [PDF]

Ecol Evol
Mendes ETB, Portela RCQ.
europepmc   +1 more source

LC-Based Metabolomics and Multivariate Analyses Reveal Metabolite Variations in Different Propagation Methods of Eurycoma longifolia Roots Harvested at Different Ages and Locations [PDF]

, 2020
Nur Nabilah Alias, Kamalrul Azlan Azizan, Norlia Basherudin, Nor Hasnida Hassan, Nazirah Abdullah   +4 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Comprehensive Assessment of Harvesting Method Effects on FAEE, Waxes, Fatty Acids, Phenolics, Volatiles, and Sensory Characteristics of Buža Virgin Olive Oil. [PDF]

Foods
Brkić Bubola K, Lukić M, Pastor I, Lukić I, Kozlovič G, Bučar-Miklavčič M, Koprivnjak O, Krapac M.   +7 more
europepmc   +1 more source

Energy harvesting using vortex-induced vibrations of tensioned cables [PDF]

, 2012
Clément Grouthier, Sébastien Michelin, Emmanuel de Langre   +2 more
openalex   +1 more source

Legal Protection of Children’s Rights That Have Sexual Harvest Reviewed from Victimology in Indonesia [PDF]

, 2020
Rahmawati Rahmawati, Hartiwiningsih Hartiwiningsih, Muhammad Rustamaji, Sulistiyanta   +3 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Clipless robotic LIMA harvesting: monitoring performance and safety through CUSUM and RA-CUSUM analyses. [PDF]

J Robot Surg
Asta L, Perfetti M, Marinelli D, Liberti G, Chiappini B, Mancini V, Greci M, D'Angelo GA, Micucci D, Pelini P, Foschi M, Rossi S, Sagazio E, D'Amico G, Mascellanti M, Zimarino M, Benedetto U.   +16 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source