Results 221 to 230 of about 1,534,598 (250)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

SMART: structured, meaningful, auditable, responsible, and transparent documentation for clinical AI. [PDF]

open access: yesJ Am Med Inform Assoc
Lohachab A   +5 more
europepmc   +1 more source

Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Anti‐amyloid antibody clinical trials with a high proportion of participants reaching treatment‐related amyloid clearance (TRAC) had positive clinical outcomes. We evaluated the aducanumab phase 3 program to determine whether TRAC during the double‐blind period was likewise associated with clinical benefit.
Menglan Pang   +8 more
wiley   +1 more source

Advanced security in fog environments using encryption and adaptive user activity tracking. [PDF]

open access: yesSci Rep
Rai HM   +5 more
europepmc   +1 more source

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