Results 41 to 50 of about 425,194 (328)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Azetidinylideneketenimines as a Multimodal Synthetic Platform: Coordination Chemistry and Cycloaddition‐Triggered Transformations

Angewandte Chemie, EarlyView.
Cross‐coupling/homologation sequence between a stable three‐membered‐ring carbene and isocyanides enables facile and rapid access to novel methyleneketenimines and the first bis(methyleneketenimine). Reactivity studies gave rise to the first methyleneketenimine‐transition metal complexes, unique multimodal reactivity ranging from CO2, isocyanate ...
Taichi Koike, Keisuke Ito, Shintaro Ishida, Takeaki Iwamoto   +3 more
wiley   +2 more sources

Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis

Quality in Sport
Introduction: Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress.
Agnieszka Starzyk, Piotr Charzewski
doaj   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Determinants of migrant inflows to Japan: a time-series analysis of pull factors

Discover Global Society
This study analyzes the determinants of migrant inflows from China, Indonesia, South Korea, Myanmar, Nepal, the Philippines, Thailand, and Vietnam, the top eight sources of foreign labor in Japan.
Shyam Kumar Karki, Mi Moe Thuzar, Tokiko Inoue   +2 more
doaj   +1 more source

Nucleus from String Theory

, 2011
In generic holographic QCD, we find that baryons are bound to form a nucleus, and that its radius obeys the empirically-known mass number (A) dependence r A^{1/3} for large A.
E. Witten, H. Liu, Koji Hashimoto, Takeshi Morita   +3 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Drug‐Induced Parkinsonism After Chronic Metoclopramide Use in an Older Woman

Clinical Case Reports
Clinicians assessing gait impairment should review the patient's medication history, and if there has been exposure to medications known to cause parkinsonism (e.g., metoclopramide), drug‐induced parkinsonism should be considered.
Sho Matsushita, Shuhei Kawabata, Ryosuke Horitani   +2 more
doaj   +1 more source

Scalar field perturbations of the Schwarzschild black hole in the G\"{o}del Universe

, 2005
We investigate the scalar field perturbations of the 4+1-dimensional Schwarzschild black hole immersed in a G\"{o}del Universe, described by the Gimon-Hashimoto solution.This may model the influence of the possible rotation of the Universe upon the ...
Abdalla, Elcio, Konoplya, R. A.
core   +3 more sources

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source