Results 71 to 80 of about 23,885 (296)

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

open access: yesAdvanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang   +5 more
wiley   +1 more source

ShinyAnonymizer Enhanced Version and Beyond: A Further Exploration of Privacy-Preserving Solutions in Health Data Management

open access: yesApplied Sciences
Healthcare institutions generate massive amounts of valuable patient data in the digital age. Finding the right balance between patient privacy and the demand for data-driven medical enhancements is essential.
Marios Vardalachakis   +2 more
doaj   +1 more source

Spectral Embedded Hashing for Scalable Image Retrieval

open access: yes, 2014
We propose a new graph based hashing method called spectral embedded hashing (SEH) for large-scale image retrieval. We first introduce a new regularizer into the objective function of the recent work spectral hashing to control the mismatch between the
Chen, L   +8 more
core   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

open access: yesAdvanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge   +6 more
wiley   +1 more source

Load Thresholds for Cuckoo Hashing with Double Hashing [PDF]

open access: yes, 2018
In k-ary cuckoo hashing, each of cn objects is associated with k random buckets in a hash table of size n. An l-orientation is an assignment of objects to associated buckets such that each bucket receives at most l objects.
Mitzenmacher, Michael   +2 more
core   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

open access: yesAdvanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu   +15 more
wiley   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

open access: yesAdvanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko   +5 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Efficient computation of spaced seed hashing with block indexing

open access: yesBMC Bioinformatics, 2018
Background Spaced-seeds, i.e. patterns in which some fixed positions are allowed to be wild-cards, play a crucial role in several bioinformatics applications involving substrings counting and indexing, by often providing better sensitivity with respect ...
Samuele Girotto   +2 more
doaj   +1 more source

Robust and secure perceptual image hashing in the transform domain [PDF]

open access: yes
The rapid development of multimedia devices such as computers, network technologies, and cell phones have made it easier for users to create, broadcast, convey, share, store, and distribute multimedia data including images, videos and audio files on a ...
Prungsinchai, Supakorn
core  

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