Results 141 to 150 of about 1,084,168 (352)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The Judean desert monasteries in the Byzantine period [PDF]
, 1996 Reviewed Book: Hirschfeld, Yizhar. The Judean desert monasteries in the Byzantine period.
Baglole, Kevin J.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Clinical EpidemiologyPengfei Guo,1,2 Caroline H Johnson,1,2 Hong Yan,1– 3 Jingyuan Xiao,1,2 Courtney Dennis,4 Kerry A Pierce,4 Andrew T DeWan,2,5 Zeyan Liew1,2 1Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA; 2Yale Center for ...
Guo P +7 more
doaj
Have Countries with Lax Environmental Regulations a Comparative Advantage in Polluting Industries? [PDF]
We aim to study whether lax environmental regulations induce comparative advantages, causing the least-regulated countries to specialize in polluting industries.
Persson, Martin +2 more
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Testing Commodities as Safe Haven and Hedging Instrument on ASEAN's Five Stock Markets [PDF]
, 2017 This study attempts to analyze commodity market instruments such as gold, silver, platinum, palladium, and West Texas Intermediate (WTI) crude oil's potential as hedge and safe haven toward some stock markets in South East Asia such as in Indonesia ...
Robiyanto, R. (Robiyanto)
core
Principles of QSAR models validation: internal and external
, 2007 P. Gramatica
semanticscholar +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Getting beyond carry trade: what makes a safe haven currency? [PDF]
There is already a substantial literature documenting the fact that low yield currencies typically appreciate during times of global financial stress and behave as safe havens. The main objective of this paper is to find out what the fundamentals of safe
Habib, Maurizio Michael, Stracca, Livio
core