Results 91 to 100 of about 63,256 (254)
Advanced Science, EarlyView.An in‐situ spacer‐cation construction strategy is developed by inducing strong hydrogen bonding between n‐hexyl phosphonic acid (HPA) and FA+, forming a stable N‐type 2D/3D perovskite heterostructure. This approach suppressed defect formation, promoted electron transport, and improved intrinsic stability, delivering 26.32% PCE, excellent operational ...
Min Liu +10 more
wiley +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
Preventing Chronic Disease, 2007 IntroductionPhysical inactivity and lower levels of education are associated with increased risk for obesity and chronic disease. Compared with other racial/ethnic groups in Hawai‘i, Native Hawaiians have a higher prevalence of chronic disease, including
Jamie K. Boyd, PhD, APRN +1 more
doaj
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
Clinical Ophthalmology, 2009 Ming Chen1, Henry W Sweeney2, Becky Luke3, Mindy Chen4, Mathew Brown51University of Hawaii, Honolulu, Hawaii, USA; 2Research Support Services, the Queens Medical Center, Honolulu, Hawaii, USA; 3Surgical Suite, Honolulu, Hawaii, USA; 4University of ...
Ming Chen +4 more
doaj
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Ensemble downscaled climate dataset for Alaska and Hawaii under historical and future conditions
Scientific DataWhile high-resolution future climate data are increasingly available for the contiguous United States, there has been limited focus on Alaska and Hawaii.
Taereem Kim +5 more
doaj +1 more source