Results 111 to 120 of about 63,256 (254)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Racial/ethnic disparities in neighborhood physical activity environments: Comparing Native Hawaiian and Other Pacific Islander and Asian Americans in the United States. [PDF]

SSM Popul Health
Xiong N, Wan N, Wen M.
europepmc   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Do negative social ties accelerate aging in adults, or does aging erode social ties? [PDF]

Proc Natl Acad Sci U S A
Zhang Q.
europepmc   +1 more source

Single‐Sensor Vibration Sensing in Anisotropic Composites Enabled by Disordered Metasurfaces

Advanced Science, EarlyView.
This work develops a single‐sensor vibration sensing (SSVS) framework that integrates disordered metasurfaces with compressive sensing. Comprehensive numerical and experimental validations demonstrate that, by manipulating anisotropic guided wave propagation through metasurfaces, the proposed SSVS framework enables high‐fidelity multi‐source vibration ...
Jianjie Zhang, Lanhe Xu, Zhongzheng Zhang, Yongbo Li, Eric Li, Asoke K. Nandi, Bing Li   +6 more
wiley   +1 more source

A Metal-Associated Epithelioid Angiosarcoma: A Case Report and Literature Review. [PDF]

Hawaii J Health Soc Welf
Chan S, Horng J, Hasegawa ME, Saito S, Rimm JB, Vierkoetter K, Mitsunaga M.   +6 more
europepmc   +1 more source

Dicationic Ion‐Pair Doping Enables Stable and High‐Performing Conducting Polymers for Organic Thermoelectrics

Advanced Science, EarlyView.
TAB–2TFSI enables efficient ion‐pair doping across a wide range of conjugated polymers, where the strongly oxidizing TAB core drives charge transfer, and the TFSI counterions promote favorable ionic compensation. This dicationic dopant promotes uniform dopant distribution, improves structural order, and increases carrier delocalization, establishing a ...
Juhyung Park, Shubhradip Guchait, Tanmay Sinha, Cynthia Verduyckt, Vijitha Ignatious, Tzu‐Yi Yu, Heyi Xia, Altynay Kaidarova, Michael Ng, Siebe Detavernier, Martin Rosenthal, Maristella Alessio, Daniel Escudero, Guy Koeckelberghs, Francisco Molina‐Lopez   +14 more
wiley   +1 more source

Problem-Based Learning (PBL) Model in Teaching Medical Laboratory Science at University of Hawai'i. [PDF]

Hawaii J Health Soc Welf
Nxedhlana V.
europepmc   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

An Ex Vivo Study Measuring the Effects of Circumferential and Near-Circumferential Closed Incisional Negative Pressure Wound Therapy Dressings on a Porcine Model. [PDF]

Hawaii J Health Soc Welf
Hasegawa ME, Livingstone J, Chan SK, Rimm JB, Burnham M, Murray P.   +5 more
europepmc   +1 more source