Results 41 to 50 of about 723,140 (343)
Evaluation of Variability Concepts for Simulink in the Automotive Domain [PDF]
, 2015 Modeling variability in Matlab/Simulink becomes more and more important. We took the two variability modeling concepts already included in Matlab/Simulink and our own one and evaluated them to find out which one is suited best for modeling variability in
Kolassa, Carsten +2 more
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Connectivity of Striped Marlin From the Central North Pacific Ocean
Frontiers in Marine Science, 2022 Striped marlin, Kajikia audax, have been in overfished condition in the Western and Central North Pacific, and overfishing is still occurring, prompting an urgent need to devise conservation and management measures based on the best, current information ...
Chi Hin Lam +4 more
doaj +1 more source
Hawaii Health Gaps Report: What's Driving Health Differences Across the State and How Can Those Gaps Be Closed? [PDF]
, 2015 Why is there so much difference in the health of residents in one county compared to other counties in the same state? In this report, the County Health Rankings & Roadmaps program explores how wide gaps are throughout Hawaii and what is driving those ...
Bridget Catlin +2 more
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
The Effect of Hawaii’s Vast Diversity on Racial and Social Prejudices [PDF]
, 2016 Food is the universal language of the world, and Hawaiians speak SPAM. Hawaii is the largest consumer of SPAM in the world, with their own signature recipe, as well as an annual SPAM party which over 20,000 people attend.
Frigerio, Alexandra
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Measurement of CFHT Images I: Identification, Photometry and Classification [PDF]
, 2014 In this paper we present preliminary results from the measurement and analysis of imag es of the ecliptic zoneobtained with MegaCam at Canada-France-Hawaii Telescope (CFHT) located a t Mauna Kea(Hawaii ).
Bustos Fierro, Iván Heriberto +1 more
core +2 more sources
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source