Angewandte Chemie, EarlyView.Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic +18 more
wiley +2 more sources
Measuring Temporal Instability of Momentary Affect, Subjective Health and Symptom Burden Depending on Environmental Parameters-An Ambulatory Assessment Study in Persons with Hay Fever. [PDF]
Int J Environ Res Public Health, 2021 Rostalski T, Schmidt S, Muehlan H.
europepmc +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Emerging evidence suggests a possible link between rhinosinusitis and systemic rheumatic diseases; however, no meta‐analysis has comprehensively examined this association to date. We aimed to investigate if patients with rhinosinusitis have a predisposition to unmasking rheumatic diseases compared to individuals without ...
Arshbir Aulakh +5 more
wiley +1 more source
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT
Health Technology AssessmentBackground Atopic eczema is a common childhood skin problem linked with asthma, food allergy and allergic rhinitis that impairs quality of life. Objectives To determine whether advising parents to apply daily emollients in the first year can prevent ...
Lucy E Bradshaw +24 more
doaj +1 more source
Art. XXII.—Autumnal Catarrh (Hay Fever). With three Maps. [PDF]
, 1872 Morrill Wyman
openalex +1 more source
Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons
Animal Models and Experimental Medicine, EarlyView.Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft +18 more
wiley +1 more source
Children with atopic eczema experiencing increased disease severity in the pollen season more often have hay fever at a young age and a dark skin type. [PDF]
J Dermatol, 2021 Bosma AL +2 more
europepmc +1 more source
This year's experience with the treatment of hay fever for stay‐at‐homes [PDF]
, 1899 Scheppegrell
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Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis
Annals of Neurology, EarlyView.Objective A better understanding of factors associated with multiple sclerosis (MS) disease activity and disability is needed. Given the strong link between comorbid depression and MS disease activity and disability, we aimed to determine whether the depression genetic burden, as modelled using its polygenic score, is associated with MS disease ...
Ali Manouchehrinia +24 more
wiley +1 more source