Results 271 to 280 of about 848,198 (341)

Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome presenting as aseptic pustular dermatosis: A rare clinical manifestation

open access: yes
Arthritis &Rheumatology, Accepted Article.
Peter Chen   +6 more
wiley   +1 more source

Effectiveness and safety of interventions for fever‐associated discomfort in children: A systematic review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Fever is one of the most frequent reasons for paediatric consultations. While traditionally managed by reducing body temperature, recent guidelines emphasize alleviating discomfort as the primary therapeutic goal. Although different interventions have been described to manage fever‐associated discomfort in children, their effectiveness and safety ...
Antonio Corsello   +8 more
wiley   +1 more source

GRAZAX®: a sublingual immunotherapy vaccine for Hay fever treatment: from concept to commercialization. [PDF]

open access: yesHum Vaccin Immunother, 2019
Barber D   +5 more
europepmc   +1 more source

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

open access: yesJournal of Allergy and Clinical Immunology, 2014
M. Ferreira   +33 more
semanticscholar   +1 more source

Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims In haematopoietic cell transplantation (HCT), neutropenia resulting from myelosuppression is an expected endpoint following busulfan‐based conditioning. However, if prolonged, neutropenia can lead to complications like serious infection and death.
Beth Apsel Winger   +6 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort   +3 more
wiley   +1 more source

Hay fever in childhood, traits Neuroticism and Conscientiousness as independent predictors of the occurrence of hay fever in adulthood. [PDF]

open access: yesJ Health Psychol, 2016
Cheng H   +6 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort   +8 more
wiley   +1 more source

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