Results 311 to 320 of about 848,198 (341)

UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Sacituzumab govitecan (SG), a humanized antibody‐drug conjugate, enables intra‐tumor delivery of SN‐38, the active metabolite of irinotecan, with the aim of increasing efficacy. SN‐38 is predominantly inactivated by the polymorphically expressed uridine diphosphate glucuronosyltransferase 1A1 (UGT1AA) where reduced activity can lead to toxicity.
Cinzia Dello Russo, Innocent Gerald Asiimwe, Sudeep Pushpakom, Carlo Palmieri, Munir Pirmohamed   +4 more
wiley   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi, Cole Cornwell, Kyunghee Yang, Paul M. Beringer   +3 more
wiley   +1 more source

Transverse colon perforation secondary to necrotizing pancreatitis: a rare and life-threatening complication. [PDF]

J Surg Case Rep
Derkaoui A, Deflaoui T, Aissi I, Hassani M, Karmouni S, Guellil A, Jabi R, Bouziane M.   +7 more
europepmc   +1 more source

Risk factors for asthma across India: Results from global asthma network (GAN) phase I study. [PDF]

Lung India
Singh S, Salvi S, Kabra SK, Singh M, Awasthi S, Mahesh PA, Sharma AK, Mohammed S, Sukumaran TU, Ghoshal AG, Singh N, Mangal DK, Barne M, Sinha S, Kochar SK, Singh U, Mishra A, Singh V.   +17 more
europepmc   +1 more source

Q Fever: Who Is at Risk? A Serological Survey in the General Population and Occupationally Exposed Individuals in Northern Italy. [PDF]

Pathogens
Fincato A, Lucchese L, Bellinati L, Mazzotta E, Ragolia S, Asa'Ad S, Salata C, Natale A.   +7 more
europepmc   +1 more source

National Pollen and Aerobiology Research Unit : Annual Research and Knowledge Transfer Report 2007 - 2008 [PDF]

Emberlin, Jean
core  

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HAY-FEVER AND HAY-FEVER POLLENS

Archives of Internal Medicine, 1917
The causative relationship of pollens to hay-fever has become so well established that it appears almost superfluous to offer additional evidence. The experience of the past year in the correspondence of the American Hay-Fever-Prevention Association, however, has shown that there are still many who doubt that hay-fever is caused by pollen, and that ...
openaire   +2 more sources

Hay Fever Therapy

Annals of Internal Medicine, 1972
Excerpt To the editor: The report by Lichtenstein, Norman, and Winkenwerder, "A Single Year of Immunotherapy for Ragweed Hay Fever" [Ann Intern Med75:663-671, 1971], leaves certain points that coul...
C. Raymond Zeiss, Roy Patterson, Jacob J. Pruzansky   +2 more
openaire   +3 more sources

 Grazax for hay fever?

Drug and Therapeutics Bulletin, 2008
Over 1 in 5 adults in the UK are estimated to have allergic rhinitis and around half of these people are allergic to grass pollen. Despite optimal use of intranasal corticosteroids and oral antihistamines, some patients continue to have troublesome symptoms.
openaire   +2 more sources

Hay Fever is Associated with Prevalence, Age of Onset and Persistence of Stuttering

, 2020
V. Ajdacic-Gross, S. Rodgers, Mario Müller, R. von Känel, E. Seifritz, E. Castelao, M. Strippoli, C. Vandeleur, M. Preisig, P. Howell   +9 more
semanticscholar   +1 more source