Results 31 to 40 of about 634,600 (245)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

“Green grabbing,” pastoralism and environmental dynamics in Northern Kenya. An assessment of conservation models and practices in Marsabit County

Les Cahiers d’Afrique de l’Est, 2015
In Northern Kenya, the history of protected areas reflects the debates that have shaped the world of conservation and environmental concerns. For a long time colonial assumptions about pastoralist uses of natural resources have been part of environmental
Benoit Hazard, Christine Adongo
doaj   +1 more source

Stability Analysis of “Support-Surrounding Rock” System for Fully Mechanized Longwall Mining in Steeply Dipping Coal Seams

Shock and Vibration, 2022
The key to safe and efficient longwall mining of steeply dipping seams lies in the stability control of the “support-surrounding rock” system. This study analyzes the difficulties encountered when controlling the stability of the support during the ...
Shenghu Luo, Tong Wang, Yongping Wu, Jingyu Huangfu   +3 more
doaj   +1 more source

Breastfeeding Benefits and Resources: Breastmilk feeds more than just babies!

EDIS
This publication explains the importance of breastmilk to the infant gut microbiome. First, the gut microbiome is defined, then the source of infant microbes is introduced, and finally the role of breastfeeding in infant gut microbiome and infant health.
Diana Hazard Taft
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Analysis on the characteristics of geological disasters and effectiveness of early warning duiring heavy rainfall on “23•7” in Beijing

Zhongguo dizhi zaihai yu fangzhi xuebao
Extreme rainfall is often accompanied by mass geological disasters, which seriously endangers the safety of people 's lives and property in prone areas and affects the healthy development of the economy and society.
Yun NAN, Shuhua ZHAI, Yan LI, Ying CAO, Shoujing LUO, Yuntao WANG, Xuefei GUO   +6 more
doaj   +1 more source

The 1831 eruption of Babuyan Claro that never happened: has the source of one of the largest volcanic climate forcing events of the nineteenth century been misattributed?

Journal of Applied Volcanology, 2018
The 1831 eruption of Babuyan Claro in the Philippines is regarded as one of the most significant volcanic climate forcing events of the nineteenth century. Modern databases have assigned the eruption a VEI of 4? and Magnitude of 4.7.
Christopher S. Garrison, Christopher R. J. Kilburn, Stephen J. Edwards   +2 more
doaj   +1 more source

Hydrologic sensitivity of flood runoff and inundation: 2011 Thailand floods in the Chao Phraya River basin [PDF]

Natural Hazards and Earth System Sciences, 2015
The Thailand floods in 2011 caused unprecedented economic damage in the Chao Phraya River basin. To diagnose the flood hazard characteristics, this study analyses the hydrologic sensitivity of flood runoff and inundation to rainfall. The motivation is to
T. Sayama, Y. Tatebe, Y. Iwami, S. Tanaka   +3 more
doaj   +1 more source