Results 61 to 70 of about 678,841 (321)

Source mechanism of volcanic tectonic events from October 2010 to December 2011 at the Sinabung volcano area

open access: yesGeoscience Letters, 2022
From its first eruption at the end of August 2010, Mount Sinabung has been being seismically active. Thousands of micro earthquakes have occurred in the magma itself, in hydrothermal systems, and along nearby tectonic faults.
Afnimar   +5 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Stoichiometric homeostasis does not affect species dominance and stability in an alpine steppe, Tibetan Plateau

open access: yesArctic, Antarctic, and Alpine Research, 2019
Studies of stoichiometric homeostasis in different types of plant species growing in alpine steppe environments are important in understanding the fitness and nutrient-use strategies of alpine plants in northern Tibet, which may be correlated with ...
Jianbo Wu, Xiaodan Wang
doaj   +1 more source

The built-in selection bias of hazard ratios formalized [PDF]

open access: yesarXiv, 2022
It is known that the hazard ratio lacks a useful causal interpretation. Even for data from a randomized controlled trial, the hazard ratio suffers from built-in selection bias as, over time, the individuals at risk in the exposed and unexposed are no longer exchangeable. In this work, we formalize how the observed hazard ratio evolves and deviates from
arxiv  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Bromo activity over the last decade: consistent passive degassing and source magma evolution

open access: yesGeoscience Letters, 2022
Bromo is among the very active volcanoes in Indonesia and is known for its recurrent and long-lasting eruptive manifestations. Past volcanic gas studies have revealed Bromo as one of the principal sources of volcanic degassing in Indonesia.
Hilma Alfianti   +7 more
doaj   +1 more source

On a general structure for hazard-based regression models: an application to population-based cancer research [PDF]

open access: yesarXiv, 2018
The proportional hazards model represents the most commonly assumed hazard structure when analysing time to event data using regression models. We study a general hazard structure which contains, as particular cases, proportional hazards, accelerated hazards, and accelerated failure time structures, as well as combinations of these.
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Predicting the current fishable habitat distribution of Antarctic toothfish (Dissostichus mawsoni) and its shift in the future under climate change in the Southern Ocean [PDF]

open access: yesPeerJ
Global warming continues to exert unprecedented impacts on marine habitats. Species distribution models (SDMs) are proven powerful in predicting habitat distribution for marine demersal species under climate change impacts.
Jie Liu   +4 more
doaj   +2 more sources

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

open access: yesBMC Pharmacology and Toxicology, 2020
Background Acrylamide (ACR) formed during heating of tobacco and carbohydrate-rich food as well as widely applied in industries has been known as a well-established neurotoxic pollutant.
Jie Guo   +4 more
doaj   +1 more source

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