Results 161 to 170 of about 59,801 (304)

Seismic hazard assessment of Navarre (Northern Spain)

, 2008
The RISNAV project, financed by the Civil Defence Department of Navarre (Northern Spain), aims at assessing seismic risk of the entire region. The final goal of the project is the definition of emergency plans for future earthquakes.
Gaspar-Escribano, Jorge M., Murphy, Patrick, Rivas Medina, Alicia, Pérez Escalante, Mercedes, Tsige, Meaza, García Rodríguez, María José   +5 more
core  

Author Correction: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health. [PDF]

Arch Toxicol
Louro H, Vettorazzi A, López de Cerain A, Spyropoulou A, Solhaug A, Straumfors A, Behr AC, Mertens B, Žegura B, Fæste CK, Ndiaye D, Spilioti E, Varga E, Dubreil E, Borsos E, Crudo F, Eriksen GS, Snapkow I, Henri J, Sanders J, Machera K, Gaté L, Le Hegarat L, Novak M, Smith NM, Krapf S, Hager S, Fessard V, Kohl Y, Silva MJ, Dirven H, Dietrich J, Marko D.   +32 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Essays on intrahousehold bargaining, risk-sharing, and the optimal balance between private insurance and the welfare state [PDF]

This thesis comprises three essays in the field of applied microeconomic theory. In the first essay we present a generalized Nash model of household decision making that does not restrict a priori the household's location on the Pareto frontier and ...
Creightney, Cavelle D.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Improving the human hazard characterization of chemicals: a Tox21 update. [PDF]

Environ Health Perspect, 2013
Tice RR, Austin CP, Kavlock RJ, Bucher JR.   +3 more
europepmc   +1 more source

Scholarships or Student Loans? Subsidizing Higher Education in the Presence of Moral Hazard [PDF]

Student loans, even income-contingent ones, are not optimal. Potential university students with the appropriate characteristics should be offered a scholarship, dependent on both need and merit.
Alessandro Cigno, Annalisa Luporini
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source