Results 161 to 170 of about 2,593,582 (300)

Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health. [PDF]

Arch Toxicol
Behr AC, Fæste CK, Azqueta A, Tavares AM, Spyropoulou A, Solhaug A, Olsen AK, Vettorazzi A, Mertens B, Zegura B, Streel C, Ndiaye D, Spilioti E, Dubreil E, Buratti FM, Crudo F, Eriksen GS, Snapkow I, Teixeira JP, Rasinger JD, Sanders J, Machera K, Ivanova L, Gaté L, Le Hegarat L, Novak M, Smith NM, Tait S, Fraga S, Hager S, Marko D, Braeuning A, Louro H, Silva MJ, Dirven H, Dietrich J.   +35 more
europepmc   +1 more source

Tox21 to date: steps toward modernizing human hazard characterization. [PDF]

Environ Health Perspect, 2013
Betts KS.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Author Correction: Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health. [PDF]

Arch Toxicol
Louro H, Vettorazzi A, López de Cerain A, Spyropoulou A, Solhaug A, Straumfors A, Behr AC, Mertens B, Žegura B, Fæste CK, Ndiaye D, Spilioti E, Varga E, Dubreil E, Borsos E, Crudo F, Eriksen GS, Snapkow I, Henri J, Sanders J, Machera K, Gaté L, Le Hegarat L, Novak M, Smith NM, Krapf S, Hager S, Fessard V, Kohl Y, Silva MJ, Dirven H, Dietrich J, Marko D.   +32 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Separating Moral Hazard from Adverse Selection and Learning in Automobile Insurance: Longitudinal Evidence from France [PDF]

The identification of information problems in different markets is a challenging issue in the economic literature. In this paper, we study the identification of moral hazard from adverse selection and learning within the context of a multi-period dynamic
Pierre-Carl Michaud, Georges Dionne, Maki Dahchour   +2 more
core  

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health. [PDF]

Arch Toxicol
Louro H, Vettorazzi A, López de Cerain A, Spyropoulou A, Solhaug A, Straumfors A, Behr AC, Mertens B, Žegura B, Fæste CK, Ndiaye D, Spilioti E, Varga E, Dubreil E, Borsos E, Crudo F, Eriksen GS, Snapkow I, Henri J, Sanders J, Machera K, Gaté L, Le Hegarat L, Novak M, Smith NM, Krapf S, Hager S, Fessard V, Kohl Y, Silva MJ, Dirven H, Dietrich J, Marko D.   +32 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Improving the human hazard characterization of chemicals: a Tox21 update. [PDF]

Environ Health Perspect, 2013
Tice RR, Austin CP, Kavlock RJ, Bucher JR.   +3 more
europepmc   +1 more source