Results 201 to 210 of about 308,152 (267)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Composite Ultrasound Score Integrating VExUS Grading and Right Ventricular Function for Predicting 90-Day Heart Failure Rehospitalization: A Single-Center Retrospective Cohort Study. [PDF]

Int J Gen Med
Tang H, Teng L, Xing X, Niu Q, Guo Y, Zhu X, Liu Z.   +6 more
europepmc   +1 more source

Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates. [PDF]

J Am Stat Assoc
Guo W, Wang T.
europepmc   +1 more source

Joint Frailty Mixture Cure Model for Recurrent Event Data With Dependent Censoring: An MCEM Approach. [PDF]

Stat Med
Sultana N, Alam M, Hasinur Rahaman Khan M.   +2 more
europepmc   +1 more source

Kidney dysfunction is associated with mortality, adverse CT-based muscle metrics, and functional decline in surgically treated liposarcomas of the extremities and trunk. [PDF]

PLoS One
Kylies J, Haas F, Duprée A, Huber TB, Frosch KH, Priemel M, Kylies D.   +6 more
europepmc   +1 more source

Efficient Estimation Methods for the QR Distribution with Type-II Censored Data: An Empirical Validation on Lung Cancer Prognosis. [PDF]

Entropy (Basel)
Ramzan Q, Amin M, Alghamdi S, Alharbi R.
europepmc   +1 more source

Hazard function modeling

openaire   +1 more source

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On Discrete Hazard Functions

IEEE Transactions on Reliability, 1982
This paper describes basic results about discrete hazard functions. Several of these results have parallels in the continuous case. Two theorems in section three are presented. The first provides a basis for selecting hazard functions; the cumulative hazard must become infinite. The second describes the limiting behavior of residual lifetime.
Salvia, A. A., Bollinger, R. C.
openaire   +1 more source

The Reversed Hazard Rate Function

Probability in the Engineering and Informational Sciences, 1998
In this paper we discuss some properties of the reversed hazard rate function. This function has been shown to be useful in the analysis of data in the presence of left censored observations. It is also natural in discussing lifetimes with reversed time scale.
Block, Henry W., Savits, Thomas H., Singh, Harshinder   +2 more
openaire   +1 more source

Generation of hazard identification functions

Fourth International Symposium on Quality Electronic Design, 2003. Proceedings., 2004
We study the problem of identifying the complete set of pairs of input patterns that can cause different types of hazards to appear at a circuit line. A novel methodology to implicitly identify all possible input configurations is proposed. The technique is based on a systematic derivation of the conditions for the occurrence of static and dynamic ...
Michael, Maria K., Tragoudas, S., Michael, Maria K., Tragoudas, S.   +3 more
openaire   +2 more sources