Results 191 to 200 of about 439,438 (245)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Penicillin Allergy Labels, Broad-Spectrum Antibiotic Use, and Chronic Obstructive Pulmonary Disease Exacerbations: A Population-Based Cohort Study from China. [PDF]

Infect Drug Resist
Wu P, Xie T, Pan H, Tian Z, Wu B, Li Q, Chen Y, Hou X, Shao J, Gao S, Zhou X, Dong W, Xue J, Li T, Cai S, Chen Z, Liu Y, Zhou K.   +17 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Congestion, but not low cardiac output, is independently associated with acute kidney injury following contrast agent exposure. [PDF]

Front Cardiovasc Med
Haurand JM, Zweck E, Horn P, Jung C, Kelm M, Ruschitzka F, Westenfeld R, Polzin A.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Risk of hospitalization and opioid use in older people with dementia. [PDF]

BMC Geriatr
Jensen-Dahm C, Janbek J, Laursen TM, Gasse C, Waldemar G.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Face aging rate quantifies change in biological age to predict cancer outcomes. [PDF]

Nat Commun
Haugg F, Lee G, He J, Warrington A, Bontempi D, Bitterman DS, Catalano PJ, Prudente V, Pai S, Guthier C, Kann BH, Aerts HJ, Mak RH.   +12 more
europepmc   +1 more source

Temporal dynamics of prognostic factors in breast cancer survival. [PDF]

PLoS One
Tvete IF, Klemp M.
europepmc   +1 more source

Pooled analysis of 2 clinical trials of first-line chemoimmunotherapy for metastatic microsatellite stable colorectal cancer MEDITREME and METIMMOX studies. [PDF]

Oncoimmunology
Truntzer C, Thibaudin M, Bousquet PA, Peroz M, Derangère V, Ilie A, Rageot D, Flatmark K, Ree AH, Meltzer S, Ghiringhelli F.   +10 more
europepmc   +1 more source