Hazardous Substances, CERCLA, and Nanoparticles – Can the Three be Reconciled?
Toxicology research in the nanotechnology area has focused primarily on human inhalation, ingestion or dermal exposure. Less research has been published on the impact to ecological systems resulting from a release of nanomaterials.
John Bashaw Esq.
doaj +1 more source
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
The State of Middle School and High School Science Labs in the Kansas City Region [PDF]
Shares findings from an audit of 170 school science labs, and makes recommendations for improvement in the areas of safety, facilities, equipment and materials, instruction and learning, and district ...
core
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Identifying the Burdens and Opportunities for Tribes and Communities in Federal Facility Cleanup Activities: Environmental Remediation Technology Assessment Matrix For Tribal and Community Decision-Makers [PDF]
The cleanup of this country's federal facilities can affect a wide range of tribal and community interests and concerns. The technologies now in use, or being proposed by the Department of Energy, Department of Defense and other federal agencies can ...
Jeanne M. Rubin +2 more
core
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
FEMALE SEX WORKERS’ ATTITUDES TOWARD HIV TESTING: A STUDY AMONG INDIRECT SEX WORKERS IN BANTUL, YOGYAKARTA, INDONESIA [PDF]
Background: HIV prevalence among female sex workers in Indonesia is among the highest in Asia after Papua New Guinea and Malaysia. Indirect sex workers posed a heightened risk of HIV infection compared to direct sex workers because they usually earn less
Dhesi Ari Astuti +4 more
doaj
Hazardous Noxious Substance Detection Based on Hyperspectral Remote Sensing Technique
Jaejin Park +7 more
openalex +2 more sources
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source

