Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Editorial: Hazardous substances from food processing: Formation and control, biotoxicity and mitigation. [PDF]
Front Nutr, 2022 Khan IA, Wang C, Cai K.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Editorial: Risk of dietary hazardous substances and impact on human microbiota: possible role in several dysbiosis phenotypes, volume II. [PDF]
Front Microbiol, 2023 Van Pamel E +3 more
europepmc +1 more source
ATSDR public health investment : Tennessee [PDF]
CDC/ATSDR support helps Tennessee reduce exposures to hazardous substances in the environment Tennessee is one of 25 states using ATSDR cooperative agreement funds to help build their capacity to assess and respond to site-specific issues involving human
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A plan development process for solid and hazardous waste management in the Manawatu-Wanganui region: a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy at Massey University [PDF]
, 1992 This thesis uses elements of the strategic and integrated planning process models to develop a planning process for solid and hazardous waste management for use by a New Zealand regional council.
Robson, Bridget
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Evaluation of hazardous substances emitted during mask use
Environment InternationalThis study evaluated the inhalation of mask-derived materials by simulating real breathing conditions and examined how the amount of inhaled materials varies with breathing flow rate and duration. Three types of non-certified reusable masks and two types
Jongmin Park +6 more
doaj +1 more source
ATSDR public health investment : Arkansas [PDF]
CDC/ATSDR support helps Arkansas reduce exposures to hazardous substances in the environment Arkansas is one of 25 states using cooperative agreement funds from ATSDR to build their capacity to assess and respond to site-specific issues involving human ...
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source