Results 151 to 160 of about 238,148 (334)

Reassessing the History of U.S. Hazardous Waste Disposal Policy - Problem Definition, Expert Knowledge and Agenda-Setting [PDF]

open access: yes, 1997
The authors show that in the 1940\u27s technical consensus began to develop about the effects of land-based waste disposal on groundwater degradation.
Brown, Halina Szejnwald   +3 more
core   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

EXPRESS METHOD OF ESTIMATION OF THE POTENTIAL TERRITORIAL RISK IN CASE OF ACCIDENTS ON TRANSPORT

open access: yesNauka ta progres transportu, 2016
Purpose. The present research is aimed to the development of a method to assess the potential territorial risk in accidents on the railways, which takes into account the specificity of the chemically hazardous substances emission in emergency situations ...
M. M. Biliaiev, L. Ya. Muntian
doaj  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

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