Results 61 to 70 of about 238,148 (334)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Assessment of Hazards of Hazardous Chemical Industrial Toxic Substances [PDF]

, 2011
Práce pojednává o celkovém působení nebezpečí nebezpečných chemických průmyslových toxických látkách na lidský organismu, popisuje fyzikálně-chemické vlastnosti daných látek, jejich toxikologické vlastnosti a nebezpečí pro životní prostředí.
Poláček, Tomáš
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Forecasting Zones of Air Pollution from Solid Waste Landfills

Nauka ta progres transportu
Purpose. The work is aimed at developing a mathematical model that allows to quickly calculate the area of chemical air pollution during the emission of hazardous substances from solid waste landfills.
O. O. Medvedieva, S. V. Dziuba, M. M. Biliaiev, V. A. Kozachyna, P. S. Kirichenko   +4 more
doaj   +1 more source

Ant Robotic Swarm for Visualizing Invisible Hazardous Substances

Robotics, 2013
Inspired by the simplicity of how nature solves its problems, this paper presents a novel approach that would enable a swarm of ant robotic agents (robots with limited sensing, communication, computational and memory resources) form a visual ...
John Oyekan, Huosheng Hu
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

CRISPR/Cas9 gene targeting plus nanopore DNA sequencing with the plasmid pBR322 in the classroom

Journal of Microbiology & Biology Education
Both nanopore-based DNA sequencing and CRISPR/Cas-based gene editing represent groundbreaking innovations in molecular biology and genomics, offering unprecedented insights into and tools for working with genetic information.
Röbbe Wünschiers, Robert Maximilian Leidenfrost, Hauke Holtorf, Bernd Dittrich, Thomas Dürr, Jürgen Braun   +5 more
doaj   +1 more source

On-chip spectroscopy with thermally-tuned high-Q photonic crystal cavities

, 2015
Spectroscopic methods are a sensitive way to determine the chemical composition of potentially hazardous materials. Here, we demonstrate that thermally-tuned high-Q photonic crystal cavities can be used as a compact high-resolution on-chip spectrometer ...
Andreas C. Liapis, Boshen Gao, Herzberg G., Mahmudur R. Siddiqui, Robert W. Boyd, Zhimin Shi   +5 more
core   +1 more source