Results 171 to 180 of about 766,490 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

DEEP LEARNING OF SEMI-COMPETING RISK DATA VIA A NEW NEURAL EXPECTATION-MAXIMIZATION ALGORITHM. [PDF]

Ann Appl Stat
Salerno S, Zhang Z, Li Y.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USGS Earthquake Hazards Program

This is the U.S. Geological Survey Earthquake Hazards Program website. You'll find information on worldwide earthquake activity, earthquake science, and earthquake hazard reduction.

core  

The Impacts of Natural Hazards on Taiwan’s Tourism Industry

, 2012
[[abstract]]Typhoon Morakot hit Taiwan in 2009, severely damaging the Alishan National Forest Recreation Area, a famous tourist resort in Taiwan. The only highway to this area was under repair for 10 months after the typhoon.
曾塍睿;Tseng, Cheng-Jui
core  

Loneliness and all-cause mortality in the United States. [PDF]

PLoS One
Akinyemi O, Eze O, Fasokun M, Mba-Madubuike I, Ogundipe T, Singleton D, Ogunsakin A, Khalil S, Gordon K, Michael M, Hughes K, Ogundare T.   +11 more
europepmc   +1 more source

Electroshock Hazards [PDF]

Circulation, 1967
H B, Burchell, R E, Sturm
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

24/7 population modelling for enhanced assessment of exposure to natural hazards

, 2013
There is a growing need for accurate spatio-temporal population estimates free from arbitrary administrative boundaries and temporal divisions to make enhanced assessments of population exposure to natural hazards. The approach proposed here combines the
Martin, David, Smith, Alan, Cockings, Samantha   +2 more
core  

Leveraging Immersive Virtual Reality to Prevent Child Injuries in the Home: Proof-of-Concept Study. [PDF]

JMIR Pediatr Parent
Osborne MC, Zhang L, Garefino A, Freeman R.   +3 more
europepmc   +1 more source