Results 201 to 210 of about 449,131 (266)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The impact of violation of the proportional hazards assumption on the discrimination of the Cox proportional hazards model. [PDF]

Diagn Progn Res
Austin PC, Giardiello D.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inequality in human development amplifies climate-related disaster risk. [PDF]

Nat Commun
Teber K, Sippel S, Krause M, Zscheischler J, Mahecha MD.   +4 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

HazardPyMatch: A tool for identifying reproductive and other hazards in scientific laboratories. [PDF]

Cell Rep Methods
Parker EM, Zavitsanou AM, Liff C, El Houda Mimouni N, Succi I, Rogers E, Liistro M, Jeurissen D.   +7 more
europepmc   +1 more source

Development and validation of a questionnaire assessing knowledge, attitude, perception, safety practices, and health effects related to occupational hazards among e-waste workers in Malaysia. [PDF]

PeerJ
Abu Bakar AM, Nik Husain NR, Ismail AF, Kueh YC, Muhamad R, Naim F, Che Mohd Zailani NAA, Ismail AS, Aznam FA.   +8 more
europepmc   +1 more source

Estimating Baseline Survival Function in the Proportional Hazards Model Under Monotone Hazards. [PDF]

J Stat Theory Pract
Wu Y, Chappell R.
europepmc   +1 more source

Modelling longitudinal and time-to-event data: a phase IV simulation study comparing R package implementations of joint models with time-varying Cox proportional-hazards regression, and the two-stage approach. [PDF]

BMC Med Res Methodol
Heege J, Greven S, Schaeffner E, Grittner U, Aigner A.   +4 more
europepmc   +1 more source

An integrated multi-hazard assessment using machine learning in the complex terrains of Northern Pakistan. [PDF]

Sci Rep
Khan MI, Shafique M, Khattak GA, Yahya A, Badruddin IA.   +4 more
europepmc   +1 more source