Results 131 to 140 of about 416,102 (337)

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman, Victoria E. Parker, Carmel M. McEniery, Giovanni Di Stefano, Annette Hubsch, Evangelia Vamvaka, Jo Helmy, Fotini Kaloyirou, Navazh Jalaludeen, Peter Barker, Lutz Jermutus, Joseph Cheriyan, Philip Ambery, Ian B. Wilkinson   +13 more
wiley   +1 more source

Improving the clinical value and utility of CGM systems: issues and recommendations : a joint statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group [PDF]

, 2017
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towards that vision has been gradual.
Bergenstal, Richard M., Fleming, G. Alexander, Heinemann, Lutz, Holl, Reinhard W., Peters, Anne L., Petrie, John R.   +5 more
core   +2 more sources

Prospective Association Among Diabetes Diagnosis, HbA1c, Glycemia, and Frailty Trajectories in an Elderly Population

Diabetes Care, 2019
OBJECTIVE Frailty is a dynamic state of vulnerability in the elderly. We examined whether individuals with overt diabetes or higher levels of HbA1c or fasting plasma glucose (FG) experience different frailty trajectories with aging.
G. Aguayo, A. Hulman, M. Vaillant, A. Donneau, A. Schritz, S. Stranges, L. Malisoux, L. Huiart, M. Guillaume, S. Sabia, D. Witte   +10 more
semanticscholar   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Predicting Cardiovascular Risk Factors from Retinal Fundus Photographs using Deep Learning

, 2017
Traditionally, medical discoveries are made by observing associations and then designing experiments to test these hypotheses. However, observing and quantifying associations in images can be difficult because of the wide variety of features, patterns ...
Blumer, Katy, Corrado, Greg S., Liu, Yun, McConnell, Michael V., Peng, Lily, Poplin, Ryan, Varadarajan, Avinash V., Webster, Dale R.   +7 more
core   +1 more source

A Multifunctional Bread Rich in Beta Glucans and Low in Starch Improves Metabolic Control in Type 2 Diabetes: A Controlled Trial [PDF]

, 2017
: Design: Functional foods may be useful for people with diabetes. The soluble fibers beta glucans can modify starch digestion and improve postprandial glucose response.
Lante, Anna, Tessari, Paolo
core   +2 more sources

Effectiveness of Groups for Adolescents With Type 1 Diabetes Mellitus and Their Parents [PDF]

, 2013
Peer- and family-based group therapies have been used as separate interventions to improve adjustment and self-management among youth with Type 1 diabetes mellitus.
Alemzadeh, Ramin, Kaugars, Astrida S., Kichler, Jessica C., Marik, Patricia, Nabors, Laura   +4 more
core   +2 more sources

HbA1C Variability Is Strongly Associated With the Severity of Peripheral Neuropathy in Patients With Type 2 Diabetes

Frontiers in Neuroscience, 2019
Variability in HbA1c is associated with a higher risk of cardiovascular disease and microvascular complications in patients with type 2 diabetes. The present study evaluated the severity of somatic nerve dysfunction at different stages of chronic ...
Yun-Ru Lai, Wen-Chan Chiu, Chih-Cheng Huang, Nai-Wen Tsai, Hung-Chen Wang, Wei-Che Lin, Ben-Chung Cheng, Yu Su, Chih-Min Su, Sheng-Yuan Hsiao, Cheng-Hsien Lu   +10 more
semanticscholar   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, EarlyView.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes

Archives of medical science : AMS, 2019
Introduction We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e.
A. Klisić, N. Kavaric, Verica Stanišić, S. Vujčić, V. Spasojević-Kalimanovska, A. Ninić, J. Kotur-Stevuljević   +6 more
semanticscholar   +1 more source