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HBV vaccination and HBV infection induces HBV-specific natural killer cell memory
Gut, 2020ObjectiveVaccination against hepatitis B virus (HBV) confers protection from subsequent infection through immunological memory that is traditionally considered the domain of the adaptive immune system. This view has been challenged following the identification of antigen-specific memory natural killer cells (mNKs) in mice and non-human primates.
Ratna S Wijaya +15 more
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Nature Reviews Gastroenterology & Hepatology, 2019
Chronic hepatitis B virus (HBV) infection is a serious problem owing to its worldwide distribution and potential adverse sequelae that include cirrhosis and/or hepatocellular carcinoma. Current antiviral therapies have much improved outcomes, but few patients achieve the ultimate goal of hepatitis B surface antigen (HBsAg) loss (functional cure).
Y. Liaw
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Chronic hepatitis B virus (HBV) infection is a serious problem owing to its worldwide distribution and potential adverse sequelae that include cirrhosis and/or hepatocellular carcinoma. Current antiviral therapies have much improved outcomes, but few patients achieve the ultimate goal of hepatitis B surface antigen (HBsAg) loss (functional cure).
Y. Liaw
openaire +3 more sources
Getting to HBV cure: The promising paths forward
Hepatology, 2022Chronic HBV infection is a global public health burden estimated to impact nearly 300 million persons worldwide. Despite the advent of potent antiviral agents that effectively suppress viral replication, HBV cure remains difficult to achieve because of ...
S. Fung, H. Choi, A. Gehring, H. Janssen
semanticscholar +1 more source
Development of anti-HBV agents targeting HBV capsid proteins
RSC Medicinal Chemistry, 2023>Design and synthesis of anti-hepatitis B virus (HBV) agents: A small anti-HBV compound, Cpd4 (1), was identified by in silico screening. Its structure–activity relationship studies discovered a more potent derivative, TKB-HBV-CA-001 (3b).
Takuya Kobayakawa +9 more
openaire +2 more sources
Journal of Clinical Virology, 2005
Hepatocellular carcinoma (HCC) is one of the rare human neoplasms associated with viral infections. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most important etiological factors of HCC, accounting for more than 70% of cases worldwide. The risk of HCC development is greatly increased in chronic viral carriers exposed to other recognized
Delphine, Cougot +2 more
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Hepatocellular carcinoma (HCC) is one of the rare human neoplasms associated with viral infections. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most important etiological factors of HCC, accounting for more than 70% of cases worldwide. The risk of HCC development is greatly increased in chronic viral carriers exposed to other recognized
Delphine, Cougot +2 more
openaire +2 more sources
The role of HBV-induced autophagy in HBV replication and HBV related-HCC
Life Sciences, 2018Hepatitis B virus (HBV) is infecting about 364 million people around the world. It can cause various diseases, such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). However, the present anti-viral treatment in clinics is limited; studies for new therapies are highly desired.
Mingjie Xie +3 more
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HBV plus HCV, HCV plus HIV, HBV plus HIV
Current Gastroenterology Reports, 2006Coinfection of hepatitis C virus (HCV), hepatitis B virus (HBV), and HIV is common due to shared modes of transmission. These coinfections accelerate the course of chronic liver disease and facilitate progression to cirrhosis and hepatocellular carcinoma.
James S, Park +2 more
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