Results 101 to 110 of about 21,803 (222)

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

The Journal of Physiology, EarlyView.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark, Eric Rytkin, Andrei Alexandru Mircea, Igor R. Efimov   +3 more
wiley   +1 more source

Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation

Scientific Reports
Hypertrophic cardiomyopathy (HCM) is an inherited disorder characterized by left ventricular hypertrophy and diastolic dysfunction, and increases the risk of arrhythmias and heart failure.
Haruka Mori, Dongzhu Xu, Yuzuno Shimoda, Zixun Yuan, Yoshiko Murakata, Binyang Xi, Kimi Sato, Masayoshi Yamamoto, Kazuko Tajiri, Tomoko Ishizu, Masaki Ieda, Nobuyuki Murakoshi   +11 more
doaj   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Focal ischemic myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in patients with hypertrophic cardiomyopathy

BMC Cardiovascular Disorders
Background In patients with hypertrophic cardiomyopathy (HCM), ischemic myocardial fibrosis assessed by late gadolinium enhancement (I-LGE) using cardiovascular magnetic resonance (CMR) have been reported.
Yang Zhi, Fu-dan Gui, Meng Xue, Yi-tian Long, Wen Miao, You Yi, Liang-chao Gao, Fu Bing, Shu-yue Pan   +8 more
doaj   +1 more source

Implantable Cardioverter‐Defibrillators in Children: A 14‐Year Population‐Based Study

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Nationwide pediatric ICD cohort from Slovakia illustrating incidence, indications, shock outcomes, and device‐related adverse events, highlighting the predominance of secondary prevention and the clinical burden of inappropriate shocks and major complications.
Marko Bjeloševič, Peter Olejník, Jaroslav Tomko, Michal Chalupka, Viera Illíková   +4 more
wiley   +1 more source

The Diagnostic Value of PET/CT and MRI in Head and Neck Cancer of Unknown Primary

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
PET/CT demonstrates a higher diagnostic yield than MRI in detecting primary tumors in patients undergoing diagnostic work‐up for head and neck cancer of unknown primary origin. However, combining PET/CT and MRI improves overall detection rates and enhances soft tissue evaluation.
Signe Bergliot Nielsen, Mads Bøgh, Camilla Molich Hoff, Ate Haraldsen, Mathias Hald, Janne Minet Pedersen, Edith Nielsen, Mette Hjørringgaard Madsen, Thomas Kjærgaard   +8 more
wiley   +1 more source

Timely Matters: Predictors of Delay in Oral Cavity Cancer Patients Across the Care Continuum

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
ABSTRACT Objective Limited literature focuses on delays in accessing head and neck cancer (HNC) care across the entire care continuum. This study aims to describe the time to care from symptom onset to treatment completion and identify predictors of delays for oral cavity cancer patients.
Nicholas Correia, Kennedy Johnson, Megan Durr, Barbara A. Grimes, Ann A. Lazar, Urmimala Sarkar, Patrick K. Ha, Laura Chen, Katherine C. Wai, Ilya Likhterov, Sue S. Yom, Jason W. Chan, Alain P. Algazi, Hyunseok Kang, William R. Ryan, Chase M. Heaton, Ivan El‐Sayed, Jonathan George, Mary Jue Xu   +18 more
wiley   +1 more source

Equity Dashboards in a Statewide Surgical Quality Collaborative: A Mixed Methods Pre‐Implementation Study

Learning Health Systems, Volume 10, Issue 2, April 2026.
ABSTRACT Introduction Collaborative quality initiatives have leveraged performance dashboards and cross‐institutional learning to improve surgical outcomes. However, these models for quality improvement have yet to integrate tools for improving health disparities.
Erin E. Isenberg, Natalie M. Guzman, Sarah E. Bradley, Michael J. Englesbe, Pasithorn A. Suwanabol, Calista M. Harbaugh   +5 more
wiley   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, Volume 121, Issue 4, Page 870-882, April 2026.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source