Results 111 to 120 of about 21,803 (222)

Clinical Characteristics and Cardiac Magnetic Resonance Profile of PKP2 Variant-Positive Patients With a Hypertrophic Cardiomyopathy Phenotype. [PDF]

JACC Adv
Castrichini M, Garmany R, Siontis KC, Newman DB, Geske JB, Ommen SR, Schneider J, Cooper LT, Ackerman MJ, Giudicessi JR.   +9 more
europepmc   +1 more source

Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 967-978, April 2026.
Diabetes mellitus independently increases the risk of hepatic encephalopathy following TIPS placement in patients with cirrhosis. These findings emphasize the need for careful risk assessment in patients with cirrhosis and portal hypertension complications undergoing TIPS.
Michelle Spaan, Ellen Werner, Willemijn Dijkstra, Nicole E. Erler, Diederik Bijdevaate, Sarwa Darwish Murad, Milan J. Sonneveld, Caroline M. den Hoed, Anne van Eldere, Dave S. Sprengers, Willem‐Pieter Brouwer, Robert J. de Knegt, Harry L. A. Janssen, Kay Pieterman, Sandra Coenen, Raoel Maan, Adriaan J. van der Meer   +16 more
wiley   +1 more source

Evolving strategies in obstructive hypertrophic cardiomyopathy: myosin inhibitors as monotherapy compared with beta-blockers. [PDF]

Heart Fail Rev
Grupper A, Sverdlov AL, Cheema BS, Nasrollahizadeh A, Hosseini K.   +4 more
europepmc   +1 more source

Reallocating morning physical activity to later‐day activity and its association with type 2 diabetes incidence: The Maastricht Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2642-2650, April 2026.
Abstract Aims The timing of physical activity may influence metabolic health through interactions with circadian rhythms, yet its role in type 2 diabetes mellitus (T2DM) development is unclear. We investigated associations between time‐of‐day‐specific physical activity and incident T2DM, and whether theoretically reallocating activity from morning to ...
Marvin Y. Chong, Simone J. P. M. Eussen, Jeroen H. P. M. van der Velde, Bastiaan E. de Galan, Hans H. C. M. Savelberg, Hans Bosma, Martijn J. L. Bours, Matty P. Weijenberg, Annemarie Koster   +8 more
wiley   +1 more source

Evaluation of artificial intelligence-based electrocardiogram analysis tools in patients with hypertrophic cardiomyopathy. [PDF]

Eur Heart J Digit Health
Babur Guler G, Guler A, Surgit O, Turkmen I, Atmaca S, Sahin H, Pay D, Almasri M, Coskun G, Yartasi U, Salduz D, Kuru Gorgulu B, Aydin S, Serbest NG, Turkvatan Cansever A, Tanboga IH.   +15 more
europepmc   +1 more source

Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3295-3304, April 2026.
Abstract Aims Little is known about how the alignment between daily behaviours, such as physical activity and eating, and chronotype relates to glucose metabolism. We investigated whether alignment of physical activity and meal timing with chronotype was associated with glycaemic parameters and with prediabetes or type 2 diabetes (T2DM).
Marvin Y. Chong, Joseph Henson, Martijn J. L. Bours, Hans Bosma, Bastiaan E. de Galan, Carla J. H. van der Kallen, Ree M. Meertens, Hans H. C. M. Savelberg, Miranda T. Schram, Matty P. Weijenberg, Thomas Yates, Annemarie Koster, Simone J. P. M. Eussen   +12 more
wiley   +1 more source

Infantile hypertrophic cardiomyopathy masquerading as cardiac tamponade: A case report. [PDF]

SAGE Open Med Case Rep
Sembiring TSR, Adam MF.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, Volume 20, Issue 3, Page 637-667, March 2026.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Application of untargeted plasma metabolomics and machine learning to construct a diagnostic model for hypertrophic cardiomyopathy: a case-control study. [PDF]

Metabolomics
Li R, Wang B, Shan B, Sun M, Ta S, Zhao J, Kang N, Yang F, Yuan Y, Li X, Wang H, Fan L, Zheng H, Wang J, Liu L.   +14 more
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source