Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction [PDF]
ESC Heart Failure, 2023 Aims Inhibitors of SGLT2 (SGLT2i) have shown a positive impact in patients with chronic heart failure and reduced ejection fraction (HFrEF). Nonetheless, the direct effects of SGLT2i on cardiac cells and how their association with main drugs used for ...
Luis Ortega‐Paz +11 more
doaj +3 more sources
Energies, 2023 The HCPB TBS (Helium-Cooled Pebble Bed Test Blanket System) is one of the two European TBSs that will be installed and tested in the ITER reactor. The use of flanged connections in the Helium Coolant System and the Tritium Extraction System of the HCPB ...
Alessandro Venturini +2 more
exaly +4 more sources
Safety of Normothermic Cardiopulmonary Bypass in Pediatric Cardiac Surgery: A System Review and Meta-Analysis [PDF]
Frontiers in Pediatrics, 2021 Objectives: Hypothermic cardiopulmonary bypass (HCPB) has been used successfully in cardiac surgery for more than half a century, although adverse effects have been reported with its use.
Tao Xiong +12 more
doaj +2 more sources
R&D Needs for the Design of the EU-DEMO HCPB ICD Balance of Plant in FP9
Journal of Nuclear Engineering, 2022 During the Pre-Conceptual Design Phase of the EU-DEMO, two BOP solutions for WCLL and HCPB were elaborated, as close as possible to industrial standards.
Sara Perez-Martin +3 more
doaj +4 more sources
Human PD-1hiCD8+ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis [PDF]
Frontiers in Immunology, 2021 BackgroundRheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1+CD8+ T cells as well as two distinct IL-21-producing PD-1+CD4+ T
Kazuhiko Higashioka +12 more
doaj +2 more sources
Neither tranexamic acid nor ulinastatin affects the activated clotting time values in healthy volunteers and heparinized cardiovascular surgery patients [PDF]
Journal of Cardiothoracic SurgeryBackground To investigate the effects of tranexamic acid (TXA) and ulinastatin (UTI) on activated clotting time (ACT) of healthy volunteers and cardiovascular surgical patients in the in-vitro study. Methods Blood samples of ten healthy volunteers adding
Bin Jia +3 more
doaj +2 more sources
CqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 in Vibrio fluvialis [PDF]
Emerging Microbes and Infections, 2021 Vibrio fluvialis is an emerging enteric pathogen of increasing public health threat. Two quorum sensing (QS) systems, VfqI-VfqR and CqsA/LuxS-HapR, and two type VI secretion systems (T6SSs), VflT6SS1 and VflT6SS2, have been identified in V.
Xiaoshu Liu +8 more
doaj +2 more sources
Csep1P protein from Campylobacter concisus induces a chemokine-dominant inflammatory state in macrophages and enhances proinflammatory response to gut bacteria. [PDF]
PLoS PathogensTranslocation of Campylobacter concisus from the oral cavity to the intestinal tract is increasingly recognised as a contributor to inflammatory bowel disease (IBD). The C. concisus secreted protein Csep1 has emerged as a molecular marker of C.
Christopher Yau Man Luk +7 more
doaj +2 more sources
BENCHMARKING OF THE SERPENT 2 MONTE CARLO CODE FOR FUSION NEUTRONICS APPLICATIONS [PDF]
EPJ Web of Conferences, 2021 Analyses of radiation fields resulting from a deuterium-tritium (DT) plasma in fusion devices is a critical input to the design and validation of many aspects of the reactor design, including, shielding, material lifetime and remote maintenance ...
Valentine A. +3 more
doaj +1 more source
Energies, 2023 Significant design efforts were undertaken during the Pre-Concept Design (PCD) phase of the European DEMO program to optimize the helium cooled pebble bed (HCPB) breeding blanket.
Guangming Zhou +6 more
doaj +1 more source