Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction [PDF]
ESC Heart Failure, 2023 Aims Inhibitors of SGLT2 (SGLT2i) have shown a positive impact in patients with chronic heart failure and reduced ejection fraction (HFrEF). Nonetheless, the direct effects of SGLT2i on cardiac cells and how their association with main drugs used for ...
Luis Ortega‐Paz +11 more
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Safety of Normothermic Cardiopulmonary Bypass in Pediatric Cardiac Surgery: A System Review and Meta-Analysis [PDF]
Frontiers in Pediatrics, 2021 Objectives: Hypothermic cardiopulmonary bypass (HCPB) has been used successfully in cardiac surgery for more than half a century, although adverse effects have been reported with its use.
Tao Xiong +12 more
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APPLICATION OF SUPERMC3.2 TO PRELIMINARY NEUTRONICS ANALYSIS FOR EUROPEAN HCPB DEMO [PDF]
EPJ Web of Conferences, 2021 In the D-T fueled tokamak, the neutrons not only carry the approximately 80% energy released in the per fusion reaction, but also are the source of radioactivity in the fusion system.
Li Bin +5 more
doaj +4 more sources
Human PD-1hiCD8+ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis [PDF]
Frontiers in Immunology, 2021 BackgroundRheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1+CD8+ T cells as well as two distinct IL-21-producing PD-1+CD4+ T
Kazuhiko Higashioka +12 more
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Engineering Design of the European DEMO HCPB Breeding Blanket Breeder Zone Mockup
Applied Sciences, 2023 The Helium Cooled Pebble Bed (HCPB) breeding blanket is one of the two driver-blanket candidates for the European fusion demonstration power plant (EU DEMO) within the framework of the EUROfusion Consortium.
Guangming Zhou +7 more
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Fusion Engineering and Design, 2020 Abstract From 2014 to 2020, the Pre-Conceptual Design phase (PCD) of the EU DEMO has taken place. The activities in the PCD phase differ from past exercises in their strong Systems Engineering methodology, as well as for the pragmatic approach in their technology choices.
Francisco A Hernández +2 more
exaly +7 more sources
Overview of the HCPB Research Activities in EUROfusion
IEEE Transactions on Plasma Science, 2018 In the framework of the EUROfusion’s Power Plant Physics and Technology, the working package breeding blanket (BB) aims at investigating four different BB concepts for an EU demonstration fusion reactor (DEMO). One of these concepts is the helium-cooled pebble bed (HCPB) BB, which is based on the use of pebble beds of lithiated ternary compounds and Be
Francisco A Hernández +2 more
exaly +3 more sources
CqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 in Vibrio fluvialis [PDF]
Emerging Microbes and Infections, 2021 Vibrio fluvialis is an emerging enteric pathogen of increasing public health threat. Two quorum sensing (QS) systems, VfqI-VfqR and CqsA/LuxS-HapR, and two type VI secretion systems (T6SSs), VflT6SS1 and VflT6SS2, have been identified in V.
Xiaoshu Liu +8 more
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Csep1P protein from Campylobacter concisus induces a chemokine-dominant inflammatory state in macrophages and enhances proinflammatory response to gut bacteria. [PDF]
PLoS PathogensTranslocation of Campylobacter concisus from the oral cavity to the intestinal tract is increasingly recognised as a contributor to inflammatory bowel disease (IBD). The C. concisus secreted protein Csep1 has emerged as a molecular marker of C.
Christopher Yau Man Luk +7 more
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Tritium modelling in HCPB breeder blanket at a system level
Fusion Engineering and Design, 2017 Abstract Tritium behavior in a DEMO reactor is a key design issue because of its self-sufficiency and impact on safety. Considering the difficulty in handling tritium, and that the transport, diffusion and permeation phenomena involve a large number of physical properties and parameters, it is intended to prepare a simulation tool to predict its ...
Carlos Moreno +2 more
exaly +2 more sources