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Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis
Atherosclerosis, 2012HCV and NAFLD are associated with atherosclerosis in general population. The prevalence of atherosclerosis in chronic hepatitis C (CHC) patients is unknown. We hypothesized that HCV per se and HCV-related steatosis could favour atherosclerosis. Thus, in CHC patients we assessed: (a) the prevalence of atherosclerosis; (b) the role of HCV, cardio ...
Luigi Elio Adinolfi +2 more
exaly +4 more sources
Current Pharmaceutical Design, 2008
Hepatitis C virus (HCV) infection is characterized by a number of autoreactive manifestations, such as autoantibody production, cryoglobulinemia and thyroid disorders. We will analyse critically the mechanisms invoked, and partially documented, to explain such manifestations arising in genetically predisposed individuals exposed to HCV.
FERRI, SILVIA +5 more
openaire +2 more sources
Hepatitis C virus (HCV) infection is characterized by a number of autoreactive manifestations, such as autoantibody production, cryoglobulinemia and thyroid disorders. We will analyse critically the mechanisms invoked, and partially documented, to explain such manifestations arising in genetically predisposed individuals exposed to HCV.
FERRI, SILVIA +5 more
openaire +2 more sources
Seminars in Immunopathology, 2012
Chronic hepatitis C virus (HCV) infection is associated with an increase in hepatic steatosis and a decrease in serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL) and apolipoprotein B (apoB), the main protein constituent of LDL and very low-density lipoprotein (VLDL).
M F, Bassendine +4 more
openaire +2 more sources
Chronic hepatitis C virus (HCV) infection is associated with an increase in hepatic steatosis and a decrease in serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL) and apolipoprotein B (apoB), the main protein constituent of LDL and very low-density lipoprotein (VLDL).
M F, Bassendine +4 more
openaire +2 more sources
Inhibition of HCV Replication in HCV Replicon by shRNAs
Nucleosides, Nucleotides and Nucleic Acids, 2006We show that the vector-derived long dsRNA specifically inhibits the replication of HCV RNA in HCV replicon. We designed a long dsRNA targeted to the full-length HCV IRES/core elements (1-to 377-nt). Our results revealed that the replication of HCV RNA was reduced to near background levels in a sequence-specific manner by the long dsRNAs in the HCV ...
Hiroyuki, Hamazaki +4 more
openaire +2 more sources
Lymphocyte Subsets in Hemodialyzed HCV+ and HCV– Patients
Nephron, 1998The aim of our study was to get information on the immune status of patients who undergo haemodialysis in the presence of an HCV infection. This virus infects not only hepatocytes, but also blood mononuclear cells, in particular B cells [1], but we do not know the role of this lymphocyte involvement in the maintenance and progression of hepatitis.
S, Cucciaioni +6 more
openaire +2 more sources
HCV seroreactivity and detection of HCV RNA in cirrhotics
Diagnostic Microbiology and Infectious Disease, 1999This study was carried out to determine the presence of HCV infection in cirrhotic patients and to compare their serologic profiles with detection of HCV RNA by RT-PCR. Liver function profiles were assessed and correlated with infection. Coinfection of HCV with HBV was studied in the Indian context Sera from 62 patients of biopsy confirmed cirrhosis ...
N, Berry +5 more
openaire +2 more sources
HBV/HCV Coinfection in the Era of HCV-DAAs
Clinics in Liver Disease, 2019Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known.
Rashed, Abdelaal +2 more
openaire +2 more sources
Acta Obstetricia et Gynecologica Scandinavica, 1998
Knowledge about vertical transmission of HCV is still limited. In this study we followed up the virological status of a series of offspring born to anti-HCV positive, anti-HIV negative mothers.Between January 1993 and January 1995, 5000 consecutive, anti-HIV negative pregnant women were screened for anti-HCV (ELISA III) and all positive samples were ...
A. La Torre +8 more
openaire +3 more sources
Knowledge about vertical transmission of HCV is still limited. In this study we followed up the virological status of a series of offspring born to anti-HCV positive, anti-HIV negative mothers.Between January 1993 and January 1995, 5000 consecutive, anti-HIV negative pregnant women were screened for anti-HCV (ELISA III) and all positive samples were ...
A. La Torre +8 more
openaire +3 more sources
HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA
Journal of Clinical Virology, 2015Hepatitis C virus (HCV) status cannot be reliably predicted in anti-HCV positive/HCV-RNA negative individuals who may either have recovered spontaneously or have a false-positive test due to antibody cross-reaction. Investigating T lymphocyte responses in individuals with different HCV status may help understand the cellular immune mechanisms ...
Sili, Uluhan +7 more
openaire +4 more sources
HCV-related autoimmune disorders in HCV chronic infection.
La Clinica terapeutica, 2013Patients with hepatitis C virus (HCV) chronic infection may develop a great number of extrahepatic manifestations. Among these latter, mixed cryoglobulinemia (MC) represents the prototype of HCV-associated autoimmune-lymphoproliferative disorders. Other rheumatological manifestations of HCV chronic infection are Siögren syndrome, arthritis and CREST ...
Ferrari S. M. +6 more
openaire +4 more sources