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Effectiveness of simvastatin therapy in raising HDL-C in patients with type 2 diabetes and low HDL-C

Current Medical Research and Opinion, 2004
To evaluate the efficacy of high and moderate doses of simvastatin (80 and 40 mg), for raising high density lipoprotein-cholesterol (HDL-C), improving HDL sub-fractions, and affecting other parameters, including high sensitivity C-reactive protein (hs-CRP), in patients with type 2 diabetes mellitus (DM) and low HDL-C.This double-blind, placebo ...
Michael, Miller   +5 more
openaire   +2 more sources

New Drugs for HDL-C Disorders: The Beginning

Current Medicinal Chemistry, 2014
For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this ...
Duong, M., Nicholls, S.
openaire   +3 more sources

HDL-C: Role as a risk modifier

Atherosclerosis Supplements, 2011
Evidence that low-density lipoprotein-cholesterol (LDL-C) causes cardiovascular disease (CVD) is overwhelming. It has also been proven beyond all doubt that lowering the level of LDL-C using statins reduces CV risk. However, many people remain at high risk even when their level of LDL-C has been reduced by aggressive treatment with statins.
openaire   +2 more sources

Association of Non-Hdl-C-To-Hdl-C Ratio with Coronary Lesions and Its Prognostic Performance in First-Onset Nstemi

Biomarkers in Medicine, 2023
Aim: The study sought to investigate the association of non-high-density-lipoprotein cholesterol-to-high-density-lipoprotein cholesterol ratio (NON-HDL-C:HDL-C) with coronary lesions and major adverse cardiovascular events (MACE) in first-onset non-ST-segment elevation acute myocardial infarction.
Qi Mao, Jianhua Zhao, Xiaohui Zhao
openaire   +2 more sources

Association between non-HDL-C/HDL-C ratio and carotid atherosclerosis in postmenopausal middle-aged women

Climacteric, 2019
Background: A novel lipid relation, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) ratio gathers information on all atherogenic and antiatherogenic particles on a single date. The relationship between this lipid marker and the presence of carotid atherosclerotic plaque (CAP) in postmenopausal ...
W, Masson   +5 more
openaire   +2 more sources

Different association of HDL-C, apoA-I, and HDL-C/apoA-I with multiple outcomes in HFrEF patients

International Journal of Cardiology
High-density lipoprotein-cholesterol (HDL-C) has been considered a cardioprotective factor for several decades. However, its association with outcomes in patients with heart failure with reduced ejection fraction (HFrEF) remains controversial. We aimed to investigate the association of HDL-C, apolipoprotein A-I (apoA-I), and the HDL-C/apoA-I ratio with
Ayiguli, Abudukeremu   +13 more
openaire   +2 more sources

Taking aim at HDL-C

Postgraduate Medicine, 2005
Although statin therapy has revolutionized management of coronary heart disease (CHD), the lowering of low-density lipoprotein cholesterol (LDL-C) levels is not the whole story. Increased plasma concentrations of high-density lipoprotein cholesterol (HDL-C) have a cardioprotective effect that is just as important for reducing risk of heart attack and ...
openaire   +2 more sources

THE ACUTE EFFECTS OF EXERCISE AT DIFFERENT INTENSITIES ON HDL-C AND HDL-C SUDFRACTIONS

Medicine & Science in Sports & Exercise, 1992
P. M. Gordon   +6 more
openaire   +1 more source

HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research

Circulation, 2021
Alan Remaley   +2 more
exaly  

HDL Function and Atherosclerosis: Reactive Dicarbonyls as Promising Targets of Therapy

Circulation Research, 2023
Tao Huan   +2 more
exaly  

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