Results 91 to 100 of about 12,859,612 (227)

Cost Benefit Analysis: Bypass of Prešov city

MATEC Web of Conferences, 2017
The paper describes decision making process based on economic evaluation, i.e. Cost Benefit Analysis for motorway bypass of the Prešov city. Three variants were evaluated by means of the Highway Development and Management Tool (HDM-4).
Margorínová Martina, Trojanová Mária
doaj   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Use of HDM-4 model for county road management [PDF]

, 2002
Ocjenjuju se potrebe i dugoročna strategija održavanja županijskih i lokalnih cesta na području Zagrebačke županije. Analizira se stanje cestovne mreže na osnovi terenskih mjerenja i vizualnog pregleda oštećenja kolnika.
Kršić, Ivan, Sršen, Mate, Domandžić, Dražen   +2 more
core   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Adaptation of pavement deterioration models to Lithuanian automobile roads

Journal of Civil Engineering and Management, 2002
The article presents three-system modelling of road pavement deterioration used in Lithuania: HDM-III (Highway Design and Maintenance Standards Model), HDM-4 (Highway Development and Management System) and DAVASEMA—Lithuanian pavement management system ...
Aivaras Braga, Donatas Čygas
doaj   +1 more source

The role of PAR2 in regulating MIF release in house dust mite-induced atopic dermatitis

Frontiers in Immunology
Atopic dermatitis (AD) is a chronic disease characterized by relapsed eczema and intractable itch, and is often triggered by house dust mites (HDM). PAR2 is a G-protein coupled receptor on keratinocytes and may be activated by HDM to affect AD processes.
Lingxuan Zhou, Guohong Zhang, Kai Zhang, Ziyan Rao, Zhanli Tang, Yang Wang, Jiahui Zhao, Jiahui Zhao   +7 more
doaj   +1 more source

m6A‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

Allergy, EarlyView.
This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin, Baoai Han, Qiang Xie, Aikebaier Tuohuti, Weisong Cai, Peng Zhou, Jiahao Meng, Qiuyang Fu, Zuhong He, Xiong Chen   +9 more
wiley   +1 more source

Comparison of Immune Checkpoint Molecule Expression in Different Years of House Dust Mite Subcutaneous Immunotherapy on CD4+ T and Treg Cells in Children with Allergic Rhinitis

Balkan Medical Journal
Background: Allergen‐specific immunotherapy, a unique inducer of tolerance, may result in T cell exhaution. Aims: To investigate how the duration of house dust mite (HDM) subcutaneous immunotherapy (SCIT) affects the expression of major immune ...
Zeynep Hızlı Demirkale, Mehmet Fatih Alpkıray, Ayşe Engin, Aybars Deniz Sönmez, Esra Yücel, Zeynep Tamay, Cevdet Özdemir, Günnur Deniz, Esin Çetin Aktaş   +8 more
doaj   +1 more source

Factors for Success and Failure of Allergen Immunotherapy (AIT) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergy, EarlyView.
ABSTRACT Allergen immunotherapy (AIT) has been acknowledged as the only disease‐modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study results may vary substantially.
Roy Gerth van Wijk, Vera Mahler, Melanie Albrecht, Danilo di Bona, Benjamin Hofner, Jasper Kappen, Susanne Kaul, Graham Roberts, Mohamed H. Shamji, Stefan Vieths, Oliver Pfaar   +10 more
wiley   +1 more source

Calibración de los modelos de grietas y baches de pavimentos flexibles del programa HDM-4 para El Salvador

, 2010
Generalidades sobre ingeniería de pavimentos -- Modelos de deterioro de los pavimentos flexibles para HDM-4 -- Sensibilidad de los modelos de deterioro HDM-4 -- Modelos de grietas y baches de pavimentos flexibles -- Calibración de los modelos de ...
Araya Amaya, Karen Lissette, Tobar Escobar, Eunice Marcela   +1 more
core   +1 more source