Results 21 to 30 of about 3,492,057 (185)

MiRNA-146a in Mesenchymal Stem Cells Exosome Alleviates Histological Structure of Pulmonary Tissue Via IRAK1 / NF-κB Pathway in Experimentally Induced Bronchial Asthma [PDF]

The Egyptian Journal of Histology
Introduction: Bronchial asthma is a multifaceted respiratory disorder that represents a significant global public health concern, afflicting millions of individuals and resulting in considerable morbidity and mortality.Aim of Work: To unravel the ...
Eman Mohamed, Mai Samak
doaj   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Exact Values and Bounds on Covering Schemes of Strength Two

Journal of Combinatorial Designs, EarlyView.
ABSTRACT In this work, we investigate covering schemes of strength 2 over finite abelian groups, establishing new lower and upper bounds and evaluating new exact values. A main result is a new general lower bound that improves the trivial one and achieves optimality for the binary case. We also develop a recursive relation based on subsets of the group
André G. Castoldi, Anderson N. Martinhão, Emerson L. Monte Carmelo, Pablo H. Perondi, Otávio J. N. T. N. dos Santos   +4 more
wiley   +1 more source

Extraction‐dependent changes in immunoglobulin E binding profiles of processed lesser mealworm (Alphitobius diaperinus) proteins

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Alphitobius diaperinus, the lesser mealworm, is an edible insect considered safe for human consumption; however, its proteins show documented cross‐reactivity with crustacean and house dust mite (HDM) allergens, raising potential concerns for allergic populations.
Michelle M Epstein, Isabel Mafra, Carla SS Teixeira, Bruno Carriço‐Sá, Anna‐Laura Mettinger, Caterina Villa, Sahar Kazemi, Oskar Hoffmann, Joana Costa   +8 more
wiley   +1 more source

Asphalt concrete pavement strengthening and modelling of its effect on road evenness/Asfaltbetonio dangų stiprinimas ir jo įtakos kelio lygumui modeliavimas

Journal of Civil Engineering and Management, 1999
Lithuania has a sufficiently well-developed road network, the quality of which still falls very much behind the standards used in the EU. The process of pavement distress is gradually accelerated by the following factors: a considerable increase in the ...
Virgaudas Puodžiukas, Zenonas Kamaitis
doaj   +1 more source

Pacing in posttraumatic stress disorder therapy: A meta‐regression of treatment frequency and completion rates

Journal of Traumatic Stress, EarlyView.
Abstract The present study utilized posttraumatic stress disorder (PTSD) clinical trials repository data to analyze associations between treatment frequency (i.e., weekly or more than weekly) and completion outcomes across cognitive processing therapy (CPT), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR).
David M. Horton, Gan Shi, Matthew A. Davis, Peter P. Grau, Amy M. Kilbourne   +4 more
wiley   +1 more source

The evidence for commercial house dust mite immunotherapy products: A pragmatic systematic review with narrative synthesis

Journal of Allergy and Clinical Immunology: Global
House dust mite (HDM) allergen immunotherapy (AIT) has an established role in the treatment of perennial allergic rhinitis (AR) and allergic asthma (AA) triggered by HDM sensitization. We aimed to identify all double-blind, randomized, placebo-controlled
Timothy West, MBBS, FRACP, Constance H. Katelaris, MBBS, PhD, FRACP   +1 more
doaj   +1 more source