Results 191 to 200 of about 30,786 (257)

Illuminating "the dark side of the HBB": Visualizing the full spectrum of Cas9 outcomes. [PDF]

Mol Ther Nucleic Acids
Scalisi G, Laurent M, Amendola M.
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, Volume 101, Issue 4, Page 1662-1682, August 2026.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Successful Interstitial HDR Brachytherapy for Nasal Skin SCC in Xeroderma Pigmentosum: An Eight-Year Follow-Up Case Report. [PDF]

Clin Case Rep
Saraei P, Derakhshandeh V, Bagheri A.
europepmc   +1 more source

Patient‐Derived Organoid‐Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley   +1 more source

Prime editing-mediated microhomology enables efficient replacement of large DNA. [PDF]

Nucleic Acids Res
Xie Y, Li P, He Z, Huang H, Wu D, Ma Z, Feng S, Ran J, Hou K, Gao F, Du X, Capecchi MR, Wu S.   +12 more
europepmc   +1 more source

A Comprehensive Meta‐Analysis and Review of Intraoperative Radiotherapy in Colorectal Cancer: Examining Radiation Dosage, Long‐Term Prognosis, and Treatment‐Related Complications

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background The effect of device type and radiation dose in intraoperative radiotherapy (IORT) for colorectal cancer is not well established. To explore this, we reviewed studies reporting postoperative complications, disease‐free survival, local control, and long‐term survival in patients treated with non‐implantable IORT techniques—IOERT, KV ...
Chuhan Guo, Shuyang Liu, Liangliang Li, Jiayi Zhao, Hongji Zhou, Hongqiang Liu, Tong Liu, Fujian Ji   +7 more
wiley   +1 more source

CRISPR-Cas9-mediated homology-directed repair rescues the induced bone marrow failure in <i>Fancc</i> ^-/- mice. [PDF]

Mol Ther Nucleic Acids
Harikrishnan H, Lamsal M, Chan KK, Zhang J, Tian J, Fosu K, Nguyen HP, Clapp DW, Sierra Potchanant EA, Kapur R, Xiao W, Tran NT.   +11 more
europepmc   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides)

eFood, Volume 7, Issue 4, August 2026.
This study establishes that fruit color divergence in Yanjiao pepper cultivars arises from hierarchical regulation of carotenoid metabolism, driven by yellow‐blue chromaticity variation and cultivar‐specific metabolic strategies. These findings provide a mechanistic framework for breeding peppers with enhanced color stability and nutraceutical value ...
Qi Chen, Ming Wang, Minjie Duan, Youjin Hao, Jian Ming, Honghai Li   +5 more
wiley   +1 more source

Viral genome editing methods and applications in the CRISPR era. [PDF]

J Virol
Shin K, Kim ET.
europepmc   +1 more source