Results 291 to 300 of about 360,174 (367)

A Virtual-Reality System for Interacting with Three-Dimensional Models Using a Haptic Device and a Head-Mounted Display

, 2018
Elie Saad, W. Robert J. Funnell, Paul G. Kry, Nicole M. Ventura   +3 more
openalex   +2 more sources

Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Necroptosis, a key driver of disease progression, holds promise for activating antitumor immunity. The optogenetically controlled necroptosis system, optoMLKL, bypasses upstream signaling, forming functional hotspots in membranes without RIPK3 phosphorylation.
Da‐Hye Jeong, Seokhwi Kim, Han‐Hee Park, Kyoung‐Jin Woo, Jae‐Il Choi, Minji Choi, Jisoo Shin, So Hyun Park, Myung‐Wook Seon, Dakeun Lee, Jong‐Ho Cha, You‐Sun Kim   +11 more
wiley   +1 more source

syGlass: Interactive Exploration of Multidimensional Images Using Virtual Reality Head-mounted Displays

, 2018
Stanislav Pidhorskyi, Michael A. Morehead, Quinn Jones, George A. Spirou, Gianfranco Doretto   +4 more
openalex   +2 more sources

The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology

Advanced Science, Volume 12, Issue 17, May 8, 2025.
CSF dynamics are vital for neurological health. Yet accurate quantification of CSF rates is challenging. Using a novel technique in awake, freely moving rats, significantly higher secretion rates are found than in anesthetized rats. The findings highlight the importance of awake models and the adaptability of methods for studying CSF changes influenced
Trine L. Toft‐Bertelsen, Beatriche L. Edelbo, Annette B. Steffensen, Sara D. Lolansen, Jonathan H. Wardman, Dennis B. Jensen, Nanna MacAulay   +6 more
wiley   +1 more source

Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control

Advanced Science, EarlyView.
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui, Wonjoon Moon, Pu‐Ting Dong, Carolina dos Anjos, Laisa Negri, Hao Yan, Ying Wang, Joshua Tam, Tianhong Dai, R. Rox Anderson, Jeremy Goverman, Jeffrey A. Gelfand, Seok‐Hyun Yun   +12 more
wiley   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Advanced Science, Volume 12, Issue 16, April 24, 2025.
This study explores the role of gemcitabine (GEM)‐resistant pancreatic cancer‐derived extracellular vesicles (EVs) in activating pancreatic stellate cells (PSCs) and promoting extracellular matrix production. GEM‐resistant cells release higher levels of asparagine (Asn), which triggers PSC activation. Long noncoding RNA sequencing identified linc‐ZNF25‐
Miao Yu, Mingxin Su, Zhenfeng Tian, Lele Pan, Zongmeng Li, Enlai Huang, Yinting Chen   +6 more
wiley   +1 more source

Nanomedicine Penetrating Blood‐Pancreas Barrier for Effective Treatment of Acute Pancreatitis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study introduces tungsten‐based heteropolyacid nano‐antioxidants (mTWNDs), which are co‐modified with tannic acid (TA) and melanin (A). It is able to cross the damaged blood‐pancreas barrier (BPB) to reach the mitochondria of the pancreatic acinar cells (PACs) and specifically scavenge reactive oxygen species (ROS) to treat acute pancreatitis (AP)
Dan Wang, Shuya Wang, Jinjin Liu, Xiaojing Shi, Tingli Xiong, Ruishi Li, Wei Wei, Liandong Ji, Qiong Huang, Xuejun Gong, Kelong Ai   +10 more
wiley   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source