Results 91 to 100 of about 17,083,400 (305)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Utilization of Free Tissue Transfer in Head and Neck Surgery

open access: yes, 2007
Free tissue transfer is frequently incorporated into the reconstructive algorithm for a multitude of defects in the head and neck. With the increasing usage of free tissue transfer we undertook to review the most current advances in the field.
Wax, Mark K   +8 more
core   +1 more source

Do you hear where I hear?: Isolating the individualized sound localization cues.

open access: yesFrontiers in Neuroscience, 2014
It is widely acknowledged that individualized head-related transfer function (HRTF) measurements are needed to adequately capture all of the 3D spatial hearing cues.
Griffin David Romigh, Brian D Simpson
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

On Data-Driven Approaches to Head-Related-Transfer Function Personalization

open access: yes, 2017
Head-Related Transfer Function (HRTF) personalization is key to improving spatial audio perception and localization in virtual auditory displays. We investigate the task of personalizing HRTFs from anthropometric measurements, which can be decomposed ...
Griffin Romigh (20095425)   +3 more
core  

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Practical aspects of using HRTF measuring device

open access: yesArchives of Acoustics, 2014
Measurement of Head Related Transfer Function is complicated due to the object of the test, namely the transfer function of acoustical arrangement composed of pinna, head and torso.
Przemysław Plaskota, P. Pruchnicki
doaj  

The Role of Reverberation and Magnitude Spectra of Direct Parts in Contralateral and Ipsilateral Ear Signals on Perceived Externalization

open access: yesApplied Sciences, 2019
Several studies show that the reverberation and spectral details in direct sounds are two essential cues for perceived externalization of virtual sound sources in reverberant environments.
Song Li   +2 more
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera   +20 more
wiley   +1 more source

Visually adaptive virtual sound imaging using loudspeakers

open access: yes, 2008
Advances in computer technology and low cost cameras open up new possibilities for three dimensional (3D) sound reproduction. The problem is to update the audio signal processing scheme for a moving listener, so that the listener perceives only the ...
Mannerheim, P.V.H., Mannerheim, P V H
core   +1 more source

Home - About - Disclaimer - Privacy