Results 41 to 50 of about 7,463,181 (358)
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Africa: A window on challenges and opportunities for head and neck cancer
Laryngoscope Investigative Otolaryngology, 2021 Background Head and neck cancer occurs predominantly in the Developing World, with significant challenges relating to a high burden of disease, late presentation, and poor access to curative and palliative care.
Johannes J. Fagan
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
OPTIMASI UNJUK KERJA KINCIR AIR UNDERSHOT
Rekayasa Mesin, 2023 The purpose in this research, the performance of the undershot waterwheel with hydraulic channel modifications were investigated. Testing was carried out on undershot waterwheel with diameter of 0,48 m, width of 0,10 m and the number of blades of 12 ...
Agato Agato +4 more
doaj +1 more source
Codes, Cultures, Chaos, and Champions: Common Features of Legal Codification Experiences in China, Europe, and North America [PDF]
, 2003 What are the key conditions and factors that contribute to a successful effort within a political unit to create a new legal code? This article builds of the existing "comparative codification" literature by examining that question in the context of ...
Head, John W.
core +1 more source
Ultraluminous X-ray Sources and Their Nebulae [PDF]
, 2008 One of the interesting features of Ultraluminous X-ray sources is that many of them are surrounded by luminous nebulae exhibiting diverse observational properties. In different cases the nebulae are photoionized or shock-powered.
Magnus Axelsson, Pavel Abolmasov
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2010 The following is from an article in the Saturday Review, from Head's "Ephesus and Its Coinage," and serves to show the importance numismatics occupies as a key to historical ...
Head, Barclay Vincent
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