Results 101 to 110 of about 1,587,729 (380)

The head and neck cancer immune landscape and its immunotherapeutic implications.

JCI Insight, 2016
Recent clinical trials have demonstrated a clear survival advantage in advanced head and neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade.
Rajarsi Mandal, Y. Şenbabaoğlu, A. Desrichard, J. Havel, Martin G. Dalin, N. Riaz, Ken-Wing Lee, I. Ganly, A. Hakimi, T. Chan, L. Morris   +10 more
semanticscholar   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Performance of the resurfaced hip. Part 1: the influence of the prosthesis size and positioning on the remodelling and fracture of the femoral neck

, 2010
Hip resurfacing is an established treatment for osteoarthritis in young active patients. Failure modes include femoral neck fracture and prosthesis loosening, which may be associated with medium-term bone adaptation, including femoral neck narrowing and ...
Browne, Martin, Dickinson, Alexander, Taylor, Andrew C.   +2 more
core   +1 more source

Subcutaneous emphysema during root canal therapy: endodontic accident by sodium hypoclorite [PDF]

, 2017
Cervicofacial subcutaneous emphysema is defined as the abnormal introduction of air in the subcutaneous tissues of the head and neck. It is mainly caused by trauma, head and neck surgery, general anesthesia, and coughing or habitual performance of ...
Battisti, Andrea, Ciolfi, Chiara, Mohsen, Mohamed, Palaia, Gaspare, Romeo, Umberto, Tenore, Gianluca   +5 more
core   +1 more source

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients.

Journal of the National Cancer Institute, 2016
BACKGROUND We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation ...
X. Castellsagué, L. Alemany, M. Quer, G. Halec, B. Quirós, S. Tous, O. Clavero, L. Alós, T. Biegner, T. Szafarowski, M. Alejo, D. Holzinger, Enrique Cadena, E. Claros, G. Hall, J. Laco, M. Poljak, M. Benevolo, Elena Kasamatsu, H. Mehanna, C. Ndiaye, N. Guimerà, B. Lloveras, X. León, J. Ruiz-Cabezas, I. Alvarado-Cabrero, C. Kang, J. Oh, M. García-Rojo, Ermina Iljazović, O. Ajayi, Flora Duarte, A. Nessa, L. Tinoco, M. A. Durán-Padilla, E. Pirog, Halina Viarheichyk, Hesler Morales, V. Costes, A. Félix, M. Germar, M. Mena, A. Ruacan, Asha Jain, R. Mehrotra, M. Goodman, L. E. Lombardi, A. Ferrera, S. Malami, E. I. Albanesi, Pablo Dabed, C. Molina, Rubén López-Revilla, V. Mandys, Manuel E González, J. Velasco, I. Bravo, W. Quint, M. Pawlita, N. Muñoz, S. de Sanjosé, F. X. Xavier Bosch   +61 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Head and Neck Manifestations of Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review. [PDF]

, 2016
OBJECTIVE: To conduct the first and only systematic review of the existing literature on head and neck manifestations of eosinophilic granulomatosis with polyangiitis to guide clinical decision making for the otolaryngologist.
Basnyat, Shristi, Goldfarb, Jared M., Nyquist, Gurston G., Rabinowitz, Mindy R., Rosen, Marc R.   +4 more
core   +1 more source

IL-13 May Could Enhance the Proliferation and Affect the Differentiation of Nasal Epithelium Basal Cells Through the mTOR/p70S6K1 Pathway in Chronic Rhinosinusitis With Nasal Polyps

Mediators of Inflammation
Conclusion: IL-13 may affect the proliferation and differentiation of nasal epithelial progenitor/stem cells through the mTOR/p70S6K1 pathway, which may affect the development of nasal polyps.
Ping Li, Tao Li, Jinfeng Luo, Peng Yu, Tao Jiang, Xiangmin Zhou, Liang Yu, Aiping Chen, Yuzhu Wan, Li Shi   +9 more
doaj   +1 more source

CANCER OF THE HEAD AND NECK

Journal of the American Medical Association, 1948
III. CANCER OF THE LARYNX Anatomically the larynx extends from the tip of the epiglottis to the inferior margin of the cricoid cartilage, and the term cancer of the larynx, therefore, includes all malignant growths arising in the epiglottis, the aryepiglottic folds, the arytenoids, the ventricular bands, the ventricles, the vocal cords, the subglottic
openaire   +4 more sources

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source