Results 151 to 160 of about 315,615 (312)

Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis

Discover Oncology
Thyroid cancer is a common endocrine malignancy associated with various inflammatory factors. This research aimed to explore the causal relationships between 41 inflammatory factors and the risk of thyroid cancer using Mendelian randomisation (MR ...
Bo Liu, Tingting Zhang, Jihua Han, Wen Bi, Chunlei Nie, Jiewu Zhang   +5 more
doaj   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients

Oncogenesis
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical for the effective repair of DNA interstrand crosslinks (ICLs). The disease is characterized by congenital abnormalities, progressing
Anne M. van Harten, Ronak Shah, D. Vicky de Boer, Marijke Buijze, Maaike Kreft, Ji-Ying Song, Lisa M. Zürcher, Heinz Jacobs, Ruud H. Brakenhoff   +8 more
doaj   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Exposure to alcohol and overall survival in head and neck cancer: A regional cohort study [PDF]

Background There is a paucity of knowledge regarding the association of alcohol use with overall survival (OS) of patients with head and neck squamous cell carcinoma (HNSCC).Methods All 1033 patients treated for new HNSCC in Southwest Finland regional ...
Denissoff Alexander, Ventela Sami, Routila Johannes, Niemela Solja, Huusko Teemu   +4 more
core   +1 more source

RNF213 governs divergent tumor-immune dynamics across human cancers: a prognostic biomarker for immunotherapy stratification

Discover Oncology
Purpose RNF213 encodes one of the largest E3 ubiquitin ligases in the human proteome, playing essential roles in ubiquitination, DNA damage repair, and immune system regulation.
Jinpeng Wen, Zhekuan Lv, Mojiao Lu, Chuanming Zheng, Changtian Yin   +4 more
doaj   +1 more source

Toward Precision Cancer Immunotherapy

Advanced Science, EarlyView.
Shuang Tang, Jean J. Zhao, Ada Hang‐Heng Wong   +2 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

YouTube and Bilibili as sources of information on oral cancer: cross-sectional content analysis study

Scientific Reports
This study aims to evaluate the informational quality of oral cancer-related videos on YouTube and Bilibili. A total of 300 oral videos that met the inclusion and exclusion criteria were selected for analysis.
Qilei zhang, Zhe Li, Huiping Zhang, Ling Han, Shugang Zhao, Siyu Jia   +5 more
doaj   +1 more source

Annual Report of the 2022 National Clinical Database: Decade‐Long Trends and Current Status of Gastroenterological Surgery in Japan

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim The National Clinical Database (NCD) of Japan is the largest nationwide registry, covering over 95% of surgeries in the country. This 2022 annual report summarizes the short‐term outcomes of gastroenterological surgeries and discusses trends and insights over the past decade.
Koshi Kumagai, Arata Takahashi, Hideki Ueno, Naoki Hiki, Yoshiki Kajiwara, Tomoki Ebata, Takao Otsuka, Taro Oshikiri, Yoshihiro Kakeji, Takanori Goi, Akio Saiura, Hiroshi Saeki, Chie Tanaka, Masanori Tokunaga, Tsutomu Fujii, Satoru Matsuda, Tsunekazu Mizushima, Hiroyuki Yamamoto, Yuko Kitagawa, Ken Shirabe   +19 more
wiley   +1 more source