Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan +5 more
wiley +1 more source
Diagnosis challenges and accessibility barriers to migraine management in Southeast Asia: results from the South-East Asia Local breAch on MigraiNe Treatment (SEALANT) study. [PDF]
Rattanawong W +17 more
europepmc +1 more source
PECULIARITIES OF HEADACHES IN CHILDREN WITH RHEUMATIC ARTHRITIS
Tatyana V. Podkletnova +3 more
openalex +1 more source
Objective Clinically relevant Alzheimer's disease co‐pathology is common in Lewy body disorders. Plasma P‐tau217 is a sensitive biomarker for amyloid and tau pathology in Alzheimer's disease. The objective was to determine if plasma P‐tau217 associates with Alzheimer's disease co‐pathology and cognition in Lewy body disorders. Methods Participants had (
Thomas F. Tropea +20 more
wiley +1 more source
Medication overuse headache from a tertiary headache center in Egypt: real-world insights. [PDF]
Nada MAF, Helmy MA, Zein MM, Hatem G.
europepmc +1 more source
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng +3 more
wiley +1 more source
Visual and headache outcomes following lumboperitoneal shunting in idiopathic intracranial hypertension: a prospective observational study. [PDF]
Haq NU +5 more
europepmc +1 more source
The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva +13 more
wiley +1 more source
Prevalence of Posterior Myofascial Chain Tightness and Presence of Myofascial Trigger Points in Subjects with Cervicogenic Headache. [PDF]
Welling A +4 more
europepmc +1 more source

