Results 71 to 80 of about 602,989 (338)
Advanced Science, EarlyView.Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch +13 more
wiley +1 more source
Behavioral and cognitive animal models in headache research
The Journal of Headache and Pain, 2019 Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relevant headache models.
D. Vurallı +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao +8 more
wiley +1 more source
BMC Neurology, 2017 Background Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a relatively new field of interest.
Michail Vikelis +5 more
doaj +1 more source
Advanced Science, EarlyView.Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang +10 more
wiley +1 more source
European Headache Federation guideline on idiopathic intracranial hypertension
The Journal of Headache and Pain, 2018 BackgroundIdiopathic Intracranial Hypertension (IIH) is characterized by an elevation of intracranial pressure (ICP no identifiable cause. The aetiology remains largely unknown, however observations made in a number of recent clinical studies are ...
J. Hoffmann +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Why do some people fear or distrust AI agents more than others? This twin study shows that negative attitudes toward AI may partly stem from genetic factors, linking them to traits like victim sensitivity and moral beliefs. These findings show that it is not only nurture but also nature that shapes our views of AI, with implications for future human–AI
Xiaojiayu Tan +7 more
wiley +1 more source
Predicting treatment response using pharmacy register in migraine
The Journal of Headache and Pain, 2019 Background Precision medicine may offer new strategies to treat migraine, and access to existing large cohorts may be a key resource to increase statistical power.
Thomas Folkmann Hansen +4 more
doaj +1 more source
The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review
AGING MEDICINE, EarlyView.Immersive technologies, especially virtual reality (VR), significantly improve the quality of life for older adults by enhancing physical health, cognitive function, and psychological well‐being. These technologies can be adapted to meet individual needs, making them an effective tool for addressing the challenges of aging.
Solmaz Sohrabei +2 more
wiley +1 more source
Could the chemical industry mitigate rapid global cooling from a catastrophic volcanic eruption?
AIChE Journal, EarlyView.Abstract Estimates based on historical data place the probability of a catastrophic volcanic eruption in the next 100 years at around one in six. Large volcanic eruptions can lead to significant global cooling for 2–4 years, with potentially devastating impacts on global agriculture.
David S. Sholl
wiley +1 more source