Results 181 to 190 of about 297,136 (308)

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

The prevalence of headache disorders among children and adolescents in Georgia: a cross-sectional schools-based study. [PDF]

J Headache Pain
Tatishvili NN, Katsarava Z, Shatirishvili T, Kipiani T, Giuashvili T, Lomsianidze M, Kotetishvili A, Kvernadze A, Tugushi I, Maghlakelidze S, Nemsadze V, Bedoshvili A, Bitskinashvili T, Sakvarelidze G, Şaşmaz T, Erdal D, Husøy AK, Uludüz D, Steiner TJ.   +18 more
europepmc   +1 more source

Advocacy for patients with headache disorders. [PDF]

eNeurologicalSci, 2023
Gouider R, Lorenz DH, Craven A, Grisold W, Dodick DW.   +4 more
europepmc   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Interictal burden, not ictal burden, drives work productivity impairment in headache disorders: insights from a Japanese cross-sectional study. [PDF]

J Headache Pain
Katsuki M, Matsumoto N, Matsumori Y, Tatsumoto M, Suzuki K, Shimazu T, Huerta MÁ, Sato D, Kikugawa K, Kamado S, O'Connor S, Ward T, Moran K.   +12 more
europepmc   +1 more source

Reliability of a telephone interview for the classification of headache disorders. [PDF]

Front Neurol, 2023
Angermaier A, Koennecke A, Kloetzer C, Strauss S, Fleischmann R.   +4 more
europepmc   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

The prevalence of headache disorders in children and adolescents in Nepal: a schools-based cross-sectional study. [PDF]

J Headache Pain
Ojha R, Karn R, Gajurel BP, Rajbhandari R, Gautam N, Deo B, Timilsina A, Adhikari A, Timasina RR, Nepal G, Şaşmaz T, Yalçın BNB, Berring-Uldum A, Husøy AK, Uludüz D, Steiner TJ.   +15 more
europepmc   +1 more source

Understanding the links between airborne hazards and headache disorders. [PDF]

Headache, 2023
Seng EK, Weinberger AH.
europepmc   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source