Results 121 to 130 of about 79,721 (310)
PROSES BERPIKIR MAHASISWA DALAM MENYELESAIKAN MASALAH MATEMATIKA BERDASARKAN DIMENSI HEALER [PDF]
, 2012 PROSES BERPIKIR MAHASISWA DALAM MENYELESAIKAN MASALAH MATEMATIKA BERDASARKAN DIMENSI HEALER Penelitian ini dilatarbelakangi oleh karakteristik matematika yang mempunyai objek yang bersifat abstrak, pentingnya proses berpikir (pemecahan masalah) dalam ...
Sri Adi, Widodo
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Miguel Perdomo Neira: healing, culture, and power in the nineteenth-century Andes
Anuario Colombiano de Historia Social y de la Cultura, 1997 Inlate April, 1872, the curandero (healer) Miguel Perdomo Neira arrived in Bogotá amid widespread rumors that he had come to heal the terminaIly ill, or lead conservatives in rebellion.
David Sollew
doaj
Outcome Versus Service Based Payment in Health Care: Lessons from African Traditional Healers [PDF]
We compare the more common physician compensation method of fee-for-service to the less common payment-for-outcomes method. This paper combines an investigation of the theoretical properties of both of these payment regimes with a unique data set from ...
Joshua Graff Zivin, Kenneth Leonard
core