Results 201 to 210 of about 1,735,909 (289)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Core-Out Fistulectomy Combined With Laser Ablation of the Trans-Sphincteric Fistula Tract: A Pilot Study of Efficacy and Safety. [PDF]

Med Sci Monit
Özoran E, Küçüksümer Ertek SZ, Sevinç MM.   +2 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comment-Box Modification to Muscle-Sparing Latissimus Dorsi Design for Microvascular Anastomosis Coverage

Plastic and Reconstructive Surgery, Global Open, 2017
Kenneth L. Fan, MD, Michael V. DeFazio, MD, Francis D. Graziano, BS, Jocelyn Lu, BS, David H. Song, MD, MBA   +4 more
doaj   +1 more source

A Histopathological Study of Induced Open Wounds Treated With Urinary Bladder Submucosa Scaffold in Rabbits. [PDF]

Vet Med Int
Alkhilani MA, Hammoodi OT, Tala'a AA, Al-Nuaimy W.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Assessment of collagen hemostatic membrane and sponge in alveolar sockets: A quasi-experimental prospective clinical study. [PDF]

Med Oral Patol Oral Cir Bucal
Sousa LL, Faco FP, Fiorin LG, Skiba TH, Fernandes JC, Fernandes GV, Martins SC, Pereira-da-Silva HD.   +7 more
europepmc   +1 more source

Healing the Whole Man [PDF]

, 1960
Roach, John J.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

New concept in wound infection management: From bacterial eradication to microbiome modulation. [PDF]

APL Bioeng
Hu T, Chen Z, Yin Z, Zhou L, Chen Q, Han Y, Li K.   +6 more
europepmc   +1 more source