Results 201 to 210 of about 1,648,841 (264)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Health-related quality of life and functional outcomes of colon cancer patients in the Netherlands: A population-based study. [PDF]

Colorectal Dis
Pennings AJ, Vink GR, van Kuijk S, Koopman M, Melenhorst J, Beets GL, May AM, Breukink SO.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Depressive symptoms are a key determinant of health-related quality of life in ICU survivors with psychological distress. [PDF]

Sci Rep
Kosilek RP, Schröder N, Sanftenberg L, Lindemann D, Beutel A, Schmidt K, Brettschneider C, König HH, Gensichen J, PICTURE Study Group.   +9 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Health Related Quality of Life Among Women with Breast Cancer in Mogadishu, Somalia. [PDF]

Breast Cancer (Dove Med Press)
Dirie AM, Ahmed NR, Dirie SA, Hassan SA, Abdi MA, Nour FE, Mohamed SA, Hassan KA, Dhiblawe SO, Fiidow OA, Jimale KA.   +10 more
europepmc   +1 more source

Validation of the KIDSCREEN-27 Health-Related Quality of Life Questionnaire in a Sample of Mexican Adolescents. [PDF]

Behav Sci (Basel)
Muñoz-Márquez A, Vargas-Salomón R, Blanco-Donoso LM, Meda-Lara RM, Juárez-Rodríguez P.   +4 more
europepmc   +1 more source

Technologies used in Parkinson's disease: a meta-analysis of their effect on health-related quality of life. [PDF]

J Neurol
Fidan C.
europepmc   +1 more source