Results 241 to 250 of about 4,576,456 (308)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Assessing the impact of proton versus photon therapy on health-related quality of life in lung cancer. [PDF]

Clin Transl Radiat Oncol
Sugden BM, Witlox WJA, Cortiula F, Hendriks LEL, van Loon J, Jacobs M, Hattu D, Joore MA, Ramaekers BLT, De Ruysscher DKM.   +9 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Health-related quality of life after HPB surgery. [PDF]

Surg Open Sci
Zaydfudim VM.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Commentary on "Health-related quality-of-life, complications, and mortality rates after geriatric acetabular fracture". [PDF]

Int J Surg
Yang C, Liu A, Zhao W.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Lifestyle behaviors and health-related quality of life: a comparative analysis of older and non-older adults. [PDF]

Arch Public Health
Zhao L, Wu J, Dong W, Li Q, Ma M, Feng Y, Shen Z, Guo X, Tarimo CS, Miao Y.   +9 more
europepmc   +1 more source

The Impact of Hepatitis C and Socio-Demographic Variables on Health-Related Quality of Life in Pakistan: Cross-Sectional Study. [PDF]

J Viral Hepat
Niyomsri S, Lim AG, Arif A, Asim M, Chaudhry A, Choudhry N, Hasnain A, Kemos P, Metcalfe C, Choudhry A, Hamid SS, Niaz S, Qureshi H, Foster GR, Vickerman P, Walker JG, HepFreePak team.   +16 more
europepmc   +1 more source