Results 101 to 110 of about 27,857,248 (401)

WHO global strategy to eliminate cervical cancer as a public health problem: An opportunity to make it a disease of the past

, 2020
Princess Nothemba Simelela
openalex   +1 more source

Kazakhstan: health system review

, 2012
xx, 154 p.Since becoming independent, Kazakhstan has undertaken major efforts in reforming its post-Soviet health system. Two comprehensive reform programmes were developed in the 2000s: the National Programme for Health Care and Development 2005–2010 ...
Rechel, Bernd, Katsaga, Alexandr, European Observatory on Health Systems and Policies, Karanikolos, Marina, Kulzhanov, Maksut, World Health Organization. Regional Office for Europe   +5 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Aldrin and dieldrin : health and safety guide

, 1989
Companion volume to: Environmental health criteria ; 91Published by the World Health Organization for the International Programme on Chemical Safety48 ...
World Health Organization, International Programme on Chemical Safety   +1 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Investing in mental health research and development [PDF]

, 1998
Ilona Blue, Trudy Harpham
openalex   +1 more source

Lithuania: health system review

, 2013
150 p.This analysis of the Lithuanian health system reviews the developmentsin organization and governance, health financing, health care provision,health reforms and health system performance since 2000.
Janoniene, Raimonda, van Ginneken, Ewout, Murauskiene, Liubove, European Observatory on Health Systems and Policies, Veniute, Marija, Karanikolos, Marina, World Health Organization. Regional Office for Europe   +6 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Climate change and the public health nutrition agenda [PDF]

, 2010
Roger Hughes
openalex   +1 more source