Results 41 to 50 of about 17,347,958 (353)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Health trends and health indicators [PDF]
BMC Proceedings, 2013 Among the myriad of indicators available for measuring health, which ones are most appropriate for following health trends over time in the elderly population? Health in older people is often characterised by the simultaneous presence of multiple conditions, with or without disease, which cannot be cured. Morbid conditions interact with the environment
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
HEALTH PERSONALITY, HEALTH ACTIVATION, AND GENERAL HEALTH [PDF]
Innovation in Aging, 2019 Abstract The purpose of this investigation was to examine associations between health personality and health activation as predictors of general health. Participants from the study included 3907 individuals 65 years of age and older from AARP® Medicare Supplement Plans insured by UnitedHealthcare Insurance Company.
Peter Martin +2 more
openaire +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Fish Health and Environmental Health [PDF]
Environmental Health Perspectives, 1990 Surveys conducted to evaluate the health of marine-bottom fishes have been conducted in the eastern and western North Atlantic for the past 15 years, usually in conjunction with fish stock assessment cruises. The health of the fish sampled was evaluated using certain integumental and skeletal lesions and anomalies as markers to signify compromised ...
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Journal of Periodontology, 2018 AbstractObjectivesTo date there is a paucity of documentation regarding definitions of periodontal health. This review considers the histological and clinical determinants of periodontal health for both intact and reduced periodontium and seeks to propose appropriate definitions according to treatment outcomes.ImportanceDefining periodontal health is ...
Lang, Niklaus P, Bartold, P Mark
openaire +5 more sources