Results 91 to 100 of about 5,610 (315)

Memory competition: A new experiment to assess unprovoked and provoked aggression

Acta Psychologica
Aggression can be provoked or unprovoked. Most studies on provoked and unprovoked aggression have used questionnaires, making it hard to quantify aggression's costs and benefits.
Xiaoke Qiu, Fenja Ziegler, Susan Chipchase, Bonaventura Majolo   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Is teachers’ mental health and wellbeing associated with students’ mental health and wellbeing? [PDF]

, 2018
BACKGROUND:Factors within the school environment may impact young people's mental health and wellbeing. The aim of this study was to understand the association between teacher and student mental health and wellbeing.
Bell, S, Brockman, R, Gunnell, David, Brockman, Rowan, Gunnell, D, Tilling, Kate, Hollingworth, William, Bell, Sarah, Campbell, R, Evans, R, Evans, Rhiannon, Murphy, Simon, Morris, Richard, Araya, Ricardo; id_orcid, Grey, J, Harding, Sarah, Araya, Ricardo, Hollingworth, W, Araya, R, Grey, Jill, Grey, Jillian, Ford, Tamsin, Morris, R, Kidger, J, Campbell, Rona, Ford, T, Kidger, Judi, Harding, S, Murphy, S, Tilling, K   +29 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Mental health and contributing factors to mental wellbeing in older people at high risk of hospitalization in Sweden [Elektronisk resurs] [PDF]

Objectives: Aging is linked to physiological changes, increased vulnerability, and often psychological, cognitive, and social changes that might affect mental health. Our aim was to explore factors that contribute to mental wellbeing in older people with
Johansson, Maria,, Johansson, Maria, Samefors, Maria,, Segernäs, Anna, Lyth, Johan, Lyth, Johan,, Segernäs, Anna,, Samefors, Maria   +7 more
core   +1 more source

The BRIDGE project: a feasibility randomised controlled trial of brief, intensive assessment and integrated formulation for young people (age 14-24) with features of borderline personality disorder (Protocol)

Frontiers in Psychiatry
BackgroundBorderline personality disorder (BPD) is a severe mental disorder that is characterised by a pervasive pattern of instability of interpersonal relationships, self-image, and mood as well as marked impulsivity.
Ruchika Gajwani, Ruchika Gajwani, Fiona Sim, Kirsty McAllister, Helen Smith, Emma McIntosh, Paul Moran, Dennis Ougrin, Michael Smith, Michael Smith, Andrew Ian Gumley, Andrew Ian Gumley, Andrew M. Chanen, Andrew M. Chanen, Helen Minnis, Helen Minnis   +15 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Contrasting dietary patterns remodel gut microbial function and generate multi-omic signatures associated with cardiometabolic markers

Gut Microbes
Diet is a modifiable determinant of gut microbiome composition, yet the impact of contrasting whole-dietary patterns on microbial metabolic capacity and coordinated host metabolic signatures remains incompletely characterized.
Jordan Stanford, Emily C. Hoedt, María Gómez-Martín, Erin D. Clarke, Kerith Duncanson, Tracy Burrows, Clare E. Collins   +6 more
doaj   +1 more source