Results 211 to 220 of about 22,351 (309)

Psychometric Evaluation of the Attune & Stimulate-Checklist for Assessing the Emotional State of People With Severe to Profound Intellectual Disabilities. [PDF]

J Appl Res Intellect Disabil
Doodeman TWM, Schuengel C, Sterkenburg PS.   +2 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Cross-cultural adaptation and validation of the Korean version of the facial disability index in patients with facial palsy. [PDF]

Sci Prog
Nam SS, Lee JY, Goo B, Kim JH, Lee SM, Kim MR, Ha IH, Lee YJ.   +7 more
europepmc   +1 more source

CRAHW, Centre for Research on Ageing, Health & Wellbeing, NHMRC

Impact, 2017
openaire   +2 more sources

Amending the Justice Reinvestment Act to Protect Victims of Domestic Violence [PDF]

, 2019
Strakna, Margaret
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Exploring associations of three evaluative subjective wellbeing measures (Cantril's ladder, life satisfaction, happiness) with 15 childhood and demographic factors across 22 countries. [PDF]

Sci Rep
Lomas T, Koga HK, Padgett RN, Pawelski JO, Kim ES, Makridis CA, Gundersen C, Bradshaw M, Pertel NL, Shiba K, Felton C, Helliwell JF, Johnson BR, VanderWeele TJ.   +13 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Silexan in the Treatment Of Posttraumatic stress disorder (STOP) trial: protocol for a 12-week randomised controlled trial of adjunctive Silexan for PTSD. [PDF]

BMC Complement Med Ther
Roebuck G, Parkin GM, O'Donnell M, Khanna R, Forbes D, Lau W, Serpell S, Al-Azzawi H, Santamaria E, Mohebbi M, Iyer R, Dean O, Kanaan RA, Hopwood M, Green JE, Berk M.   +15 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source