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Results 241 to 250 of about 22,203 (309)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source

SCN9A should not be considered an epilepsy gene; Refuting a gene-disease association. [PDF]

Epilepsia
Ghanty I +7 more
europepmc +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source

"I Want to Live: A Qualitative Investigation of Barriers and Facilitators to ART Adherence & Mental Health Maintenance in People With HIV". [PDF]

J Int Assoc Provid AIDS Care
Egger E +6 more
europepmc +1 more source

An Indian approach to health & wellbeing of building occupants

Indian Journal of Traditional Knowledge
openaire +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source

Correction: Age- and sex-related development of osteosarcopenia in the aging Octodon degus rodent model

Frontiers in Aging
Pablo Gallo-Soljancic +13 more
doaj +1 more source

Gaps and opportunities in polycystic ovary syndrome care-a qualitative study. [PDF]

F S Rep
Zhang AZ +5 more
europepmc +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source

Bridging knowledge gaps: An observational study on HPV awareness and misconceptions among young adults in China. [PDF]

PLoS One
Li M +5 more
europepmc +1 more source

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public health
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